3-Hydroxy-alpha-((methylamino)-methyl)benzolethanol-hydro-chlorid, (R) Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
R-(-)-Phenylephrine is an adrenergic α
1A receptor agonist (K
i = 1.4 μM) that demonstrates selectivity against the α
1B and α
1C receptor subtypes (K
is = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α
1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine . This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.
Chemische Eigenschaften
white to almost white crystalline powder
Verwenden
(R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.
Allgemeine Beschreibung
Odorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5.
Air & Water Reaktionen
May be sensitive to prolonged exposure to air and light. Water soluble.
Reaktivit?t anzeigen
Phenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts.
Brandgefahr
Flash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible.
Biologische Aktivit?t
α 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively.
Kontakt-Allergie
Phenylephrine hydrochloride is an alpha-adrenergic
agonist, used as a mydriatic and decongestant in
eyedrops.
Sicherheitsprofil
Poison by ingestion, intraperitoneal, subcutaneous, intravenous,and intramuscular routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.
3-Hydroxy-alpha-((methylamino)-methyl)benzolethanol-hydro-chlorid, (R) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte