Ursodeoxycholsure
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- CAS-Nr.
- 128-13-2
- Bezeichnung:
- Ursodeoxycholsure
- Englisch Name:
- Ursodeoxycholic acid
- Synonyma:
- UDCA;URSODIOL;URSODESOXYCHOLIC ACID;Ursodeoxycholic;URSODEOXYCHOLATE;3-alpha,7-beta-dihydroxy-5-beta-cholanoicacid;Tauroursodiol;Urosodeoxycholic Acid;actigall;3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oicaci
- CBNumber:
- CB1285736
- Summenformel:
- C24H40O4
- Molgewicht:
- 392.57
- MOL-Datei:
- 128-13-2.mol
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Ursodeoxycholsure Eigenschaften
- Schmelzpunkt:
- 203-204 °C (lit.)
- Siedepunkt:
- 437.26°C (rough estimate)
- alpha
- 60 º (c=2, EtOH)
- Dichte
- 0.9985 (rough estimate)
- Brechungsindex
- 60.5 ° (C=2, EtOH)
- Flammpunkt:
- 9℃
- storage temp.
- 2-8°C
- L?slichkeit
- ethanol: 50 mg/mL, clear
- pka
- pKa 5.04±0.04(H2O
t = 25.0±0.1
I = 0.00)(Approximate)
- Aggregatzustand
- Solid. Powder.
- Farbe
- White - almost white.
- Wasserl?slichkeit
- practically insoluble
- Merck
- 14,9889
- BRN
- 3219888
- InChIKey
- RUDATBOHQWOJDD-UZVSRGJWSA-N
- LogP
- 3-3.38 at 20℃
- CAS Datenbank
- 128-13-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
24/25-36-26 |
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| RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
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| WGK Germany |
2 |
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| RTECS-Nr. |
FZ2000000 |
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| F |
10 |
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| HS Code |
29181990 |
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| Toxizit?t |
LD50 in mice (g/kg): 0.1 i.v. (Ardenne, Reitnauer); in rats, mice (mg/kg): 2000, 6000 s.c.; 1000, 1200 i.p., 310, 260 i.v. (Ward) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Ursodeoxycholsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
WHITE CRYSTALLINE POWDER
Verwenden
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response. It is also used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.
Definition
ChEBI: Ursodeoxycholic acid is a bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones. It has a role as a human metabolite and a mouse metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of an ursodeoxycholate.
Allgemeine Beschreibung
Ursodeoxycholic acid (UDCA) is a secondary bile acid that helps regulate cholesterol. Mass spectrometry-based analysis of UDCA is routinely performed in clinical diagnostic testing applications such as neonatal testing of inborn errors of bile acid synthesis, differentiating among types of familial intrahepatic cholestasis, and therapeutic monitoring of patient responses to UDCA therapy. This Certified Spiking Solution
? is suitable as a starting material in preparation of linearity standards, calibrators, and controls for use in LC-MS/MS and GC/MS bile acid testing methods.
l?uterung methode
Recrystallise ursodiol from wet Et2O, EtOH or EtOH/MeOH. [Iwasaki Hoppe Seyler's Z Physiol Chem 244 181, 183 1936, Beilstein 10 III 1635.]
Ursodeoxycholsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ursodeoxycholsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 804)Lieferanten
128-13-2(Ursodeoxycholsure)Verwandte Suche:
- Ursodeoxycholic acid(micronized)
- URSODEOXYCHOLIC ACID
- URSODEOXYCHOLOC ACID
- UDCS
- 17-beta-(1-methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol
- acidoursodeossicolico
- arsacol
- cholit-ursan
- delursan
- destolit
- deursil
- litursol
- lyeton
- peptarom
- solutrat
- ursacol
- ursobilin
- ursochol
- 3a,7b-Dihydroxy-5b-cholan-24-oate
- 3a,7b-Dihydroxy-5b-cholanic acid
- 3a,7b-Dihydroxy-5b-cholanoic acid
- 3a,7b-Dihydroxycholanic acid
- 5b-Cholan-24-oic acid, 3a,7b-dihydroxy- (8CI)
- 5b-Cholanic acid, 3a,7b-dihydroxy- (7CI)
- 7b-Hydroxylithocholic acid
- Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7b)- (9CI)
- Desocol
- Desol
- NSC 683769
- Paptarom
- Urdes
- Ursolvan
- Urodeoxycholic acid
- Ursodiol, 7-Hydroxylithocholic Acid
- 3α,7β-Dihydroxy-5β-cholan-24-oic acid, 5β-Cholan-24-oic acid-3α,7β-diol, 7β-Hydroxylithocholic acid, UDCS
- Ursodeoxycholic-2,2,3,4,4-d5 acid
- Ursodeoxycholic acid，Ursodiol
- delursan 250
- Ursodiol (Ursodeoxycholic Acid)
- Ursodeoxycholic acid,3α,7β-Dihydroxy-5β-cholan-24-oic acid, 5β-Cholan-24-oic acid-3α,7β-diol, 7β-Hydroxylithocholic acid, UDCS
- Ursodiol (125 mg)
- Ursodeoxycholic Acid, EP
- Ursodesoxycholic acid (UDCA)
- 5beta-Cholanic Acid-3alpha,7beta-diol
3alpha,7beta-Dihydroxy-5beta-cholanic Acid
- Ursocol
- Ursodeoxycholic acid,99%
- Adursal
- Ursic acid
- 34784-46-7
- (3a,5b,7b)-3,7-Dihydroxycholan-24-oic acid
- 7BETA-HYDROXYLITHOCHOLIC ACID
- 6BETA-CHOLANIC ACID-3A,7BETA-DIOL
- (6-BETA)-CHOLANIC ACID-(3-ALPHA)-(7-BETA)-DIOL
- 3A,7B-DIHYDROXY-5B-CHOLAN-24-OIC ACID
- 3ALPHA, 7BETA-DIHYDROXY-5BETA-CHOLANIC ACID
- 3ALPHA,7BETA-DIHYDROXY-5BETA-CHOLAN-24-OIC ACID
- 3alpha,7beta-dihydroxy-6beta-cholan-24-oic acid
- 3ALPHA, 7BETA-DIOXYCHOLANIC ACID
