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Chenodesoxycholsure

Chenodeoxycholic acid Struktur
474-25-9
CAS-Nr.
474-25-9
Bezeichnung:
Chenodesoxycholsure
Englisch Name:
Chenodeoxycholic acid
Synonyma:
CDCA;CHENODIOL;CHENODEOXYCHOLATE;3ALPHA,7ALPHA-DIHYDROXY-5BETA-CHOLANIC ACID;Chenix;ChenodeoxychoL;3a,7a-Dihydroxy-5b-cholanoic acid;Fluibil;Kebilis;chendol
CBNumber:
CB4285737
Summenformel:
C24H40O4
Molgewicht:
392.57
MOL-Datei:
474-25-9.mol

Chenodesoxycholsure Eigenschaften

Schmelzpunkt:
165-167 °C (lit.)
Siedepunkt:
437.26°C (rough estimate)
alpha 
12 º (c=1, CHCl3)
Dichte
0.9985 (rough estimate)
Brechungsindex
1.4460 (estimate)
Flammpunkt:
9℃
storage temp. 
room temp
L?slichkeit
PRACTICALLY INSOLUBLE
Aggregatzustand
Powder
pka
pKa 4.34 (Uncertain)
Farbe
White to off-white
Wasserl?slichkeit
PRACTICALLY INSOLUBLE
Merck 
13,2062
BRN 
3219887
InChIKey
RUDATBOHQWOJDD-BSWAIDMHSA-N
LogP
3.05 at 20℃
CAS Datenbank
474-25-9(CAS DataBase Reference)
EPA chemische Informationen
Chenodiol (474-25-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 63
S-S?tze: 22-24/25-45-36/37
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS-Nr. FZ1980000
HS Code  29181990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Chenodesoxycholsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Chenodeoxycholic acid is the first agent to be introduced into the US market for the treatment of radiolucent gallstones. Large scale clinical trials have demonstrated the safety and efficacy of this agent. Chenodeoxycholic acid reduces the biliary concentration of cholesterol relative to that of bile acids and phospholipid, reducing the saturation and thus the lithogenicity of the bile. Success rates in dissolving gallstones are in the range of 50-70% within 4-24 months of treatment. Continuation of the drug after stone dissolution may be required to prevent reoccurrence. Chenodeoxycholic acid is the 7α-isomer of ursodeoxycholic acid which was introduced into the European market in 1978.
chenodeoxycholic acid structure
chenodeoxycholic acid structure

Chemische Eigenschaften

Off-White Solid

History

Chenodeoxycholic acid was isolated in 1924 from goose gall by Adolf Windaus and human gall by Heinrich Wieland.Its complete structural configuation was elucidated by Hans Lettre at the University of Gottingen.
In 1968, William Admirand and Donald Small at Boston University Medical School established that in patients with gallstones their bile was saturated with cholesterol, sometimes even exhibiting microcrystals, whereas this was not the case in normal people.It was then found that biliary levels of cholic acid and chenodeoxycholic acid were lower in patients with cholesterol gallstones than in normal people. Leslie Thistle and John Schoenfield at the Mayo Clinic in Rochester, Minnesota, then administered individual bile salts by mouth for four months and found that chenodeoxycholic acid reduced the amount of cholesterol in the bile.This led to a national collaborative study in the United States, which confirmed the effectiveness of chenodeoxycholic acid in bringing about dissolution of gallstones in selected patients. However, recent developments such as laparoscopic cholecystectomy and endoscopic biliary techniques have curtailed the role of chenodeoxycholic acid and ursodeoxycholic acid in the treatment of cholelithiasis.

Verwenden

A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus fa cilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.

Weltgesundheitsorganisation (WHO)

Chenodeoxycholic acid was introduced in 1975 for the treatment of cholelithiasis. It is available in several countries and the World Health Organization is not aware that registration has been refused in any other country.

Allgemeine Beschreibung

Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol.

l?uterung methode

This major bile acid in vertebrates (~80mg) is chromatographed on silica gel (5g) and eluted with CHCl3/EtOAc (3:2) and crystallised from EtOAc/hexane. It has IR: max 1705 cm-1(CHCl3). It also crystallises from EtOAc, EtOAc/heptane after purifying via the poorly soluble Na and K salt if necessary. [Kametani et al. J Org Chem 4 7 2331 1982, Beilstein 10 IV 1604.]

Chenodesoxycholsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chenodesoxycholsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 771)Lieferanten
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Xinyi Dajiang Chemical Co.,Ltd.
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029-86107037 13289246953
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+8615373025980
clara@hbshengyang.com China 874 58

474-25-9(Chenodesoxycholsure)Verwandte Suche:


  • Chenocedon
  • Chenocol
  • Chenodex
  • Chenofalk
  • Chenossil
  • Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7α)-
  • Cholanorm
  • Fluibil
  • Hekbilin
  • Kebilis
  • Ulmenide
  • 5-BETA-CHOLAN-24-OICACID,3-ALPHA,7-ALPHA-DIHYDROXY-
  • 3a,7a-Dihydroxy-5β-cholanic acid
  • 5β-Cholanic acid-3a,7a-diol
  • Chenodoxycholic acid
  • CHENODEOXYCHOLIC ACID CRYSTALLINE
  • CHENODEOXYCHOLIC ACID :CHOLAN-24-OICACID, 3,7-DIHYDROXY-, (3A,5B,7A)-,
  • ChenodeoxycholicAcidCp9598%Min
  • CHENODEXOXYCHOLICACID
  • (4R)-4-[(3R,5S,7R,8S,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4]
  • 5BETA-CHOLANIC ACID-3ALPHA,7ALPHA-DIOL
  • 5BETA-CHOLANIC ACID-3,7-DIOL
  • 5B-CHOLANIC ACID-3A,7A-DIOL
  • (3a,5,7a)-3,7-Dihydroxycholan-24-oic Acid
  • 17-(1-Methyl-3-carboxypropyl)etiocholane-3a,7a-diol
  • URSODEOXYCHOLOC ACID
  • 3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci
  • 3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci
  • 3,7-Dihydroxy-5-Cholanicacid
  • 3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci
  • 3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid
  • 3-alpha,7-alpha-dihydroxycholanicacid
  • 3-alpha,7-alpha-dihydroxycholansaeure
  • 7-alpha-hydroxylithocholicacid
  • anthropodeoxycholicacid
  • anthropodesoxycholicacid
  • anthropododesoxycholicacid
  • chendol
  • chenicacid
  • chenodesoxycholsaeure
  • gallodesoxycholicacid
  • 17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7a-diol
  • 7a-Hydroxylithocholic acid
  • Chendiol
  • Chenodeoxycholic acid,98%
  • Chenodeoxycholic acid,3α,7α-Dihydroxy-5β-cholanic acid, 5β-Cholanic acid-3α,7α-diol, Chenodiol
  • Chenodeoxycholic acid, 98% 5GR
  • (3α,5β,7α)-3,7-Dihydroxycholan-24-oic Acid
  • 5beta-Cholanic Acid-3alpha,7alpha-diol 3alpha,7alpha-Dihydroxy-5beta-cholanic Acid
  • 3α,7α-dehydroxy-5βcholanic acid
  • Ursodeoxycholic Acid IMpurity A
  • 3α,7α-Dihydroxy-5β-cholanic acid, 5β-Cholanic acid-3α,7α-diol, Chenodiol
  • Chenodeoxycholic acid,Chenodiol,CDCA
  • (R)-4-((3R,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
  • (R)-4-((3R,5S,7R,10S,13R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
  • URSODEOXYCHOLOC ACID,3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci
  • 5β-Cholanic acid-3α,7α-diol Chenodiol
  • CHENODEOXYCHOLIC ACID
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