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N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin

Glycocholic acid Struktur
475-31-0
CAS-Nr.
475-31-0
Bezeichnung:
N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin
Englisch Name:
Glycocholic acid
Synonyma:
GLYCITIN;cholylglycine;GLYCOCHOLIC ACID HYDRATE;N-Cholylglycine;[(3,7,12-Trihydroxy-24-oxocholan-24-yl)amino]acetic acid;GLYCOCHOLIC;N-cholyglycine;glycocholicaci;Cholylglycinate;lycocholic acid
CBNumber:
CB8378590
Summenformel:
C26H43NO6
Molgewicht:
465.63
MOL-Datei:
475-31-0.mol

N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin Eigenschaften

Schmelzpunkt:
128°C
Siedepunkt:
568.76°C (rough estimate)
Dichte
1.1336 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
Refrigerator
L?slichkeit
methanol: 0.1 g/mL, clear, colorless
Aggregatzustand
Solid
pka
4.4(at 25℃)
Farbe
White to Off-White
Wasserl?slichkeit
329.9mg/L(20 ºC)
Merck 
13,4507
Stabilit?t:
Hygroscopic
InChIKey
RFDAIACWWDREDC-NSPZZGDONA-N
LogP
1.650
CAS Datenbank
475-31-0(CAS DataBase Reference)
NIST chemische Informationen
Glycocholic acid(475-31-0)

Sicherheit

Kennzeichnung gef?hrlicher N
R-S?tze: 51/53
S-S?tze: 61
RIDADR  UN 3077 9/PG 3
WGK Germany  3

N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R51/53:Giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.

S-S?tze Betriebsanweisung:

S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

Beschreibung

Glycocholic acid is a glycine-conjugated form of the primary bile acid cholic acid and has roles in the emulsification of fats. It reduces expression of the gene encoding the farnesoid X receptor (FXR) and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells when used at a concentration of 1.6 μmol/ml. Glycocholic acid (250 μM) increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells, as well as decreases expression of the genes encoding multidrug resistance protein 1 (MDR1), MDR-associated protein 1 (MRP1), and MRP2 when used alone or in combination with epirubicin. It increases absorption of epirubicin into everted sacs of rat ileum and jejunum when used at a concentration of 250 μM. The bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases. Serum levels of glycocholic acid are elevated in patients with hepatocellular carcinoma compared with healthy individuals.

Chemische Eigenschaften

Off-White Solid

Verwenden

Labelled Glycocholic Acid. The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt.

Definition

ChEBI: A bile acid glycine conjugate having cholic acid as the bile acid component.

l?uterung methode

Glycocholic acid crystallises from hot water as the sesquihydrate. Dry it at 110o in vacuo. An analytical sample is prepared by suspending the acid (4g) in H2O (400mL) at ~20o, heating to boiling with slow stirring, filtering hot and allowing to cool to ~20o. The acid is filtered off, washed with H2O, dried in air, recrystallised from 5% aqueous EtOH, washed well and dried over P2O5 in a moderate vacuum to constant weight. Recrystallisation from EtOH/EtOAc, and drying, gave the anhydrous acid. [Cortese & Bauman J Am Chem Soc 57 1393 1935, Bergstrom & Norman Acta Chem Scand 7 1126 1953, Beilstein 10 IV 2077.]

N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 346)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED
+8618523575427
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Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
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Mandy@hangyubiotech.com China 10986 58
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airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
Fuzhou Lista Biotechnology Co.,Ltd

sallychris2021@gmail.com China 75 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+8615350851019
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55

475-31-0(N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin)Verwandte Suche:


  • GLYCOCHOLIC ACID
  • GLYCOCHOLIC
  • CHOLYLGLYCINE HYDRATE
  • Glycine, N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]-
  • N-((3,5,7,12)-3,7,12-Trihydroxy-24-oxocholan-24-yl)glycine
  • 5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL N-(CARBOXYMETHYL)-AMIDE
  • 5BETA-CHOLANIC ACID-3ALPHA,7ALPHA,12ALPHA-TRIOL 24-N-(CARBOXYMETHYL)-AMIDE
  • 3a,7a,12a-trihydroxy-5b-cholan-24-oic acid n-(carboxymethyl)amide
  • 3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-[CARBOXYMETHYL]AMIDE
  • 3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-(CARBOXYMETHYL) AMIDE, HYDRATE
  • N-[3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-24-OXOCHOLAN-24-YL]GLYCINE
  • N-(3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-24-OXOCHOLAN-24-YL)-GLYCINE HYDRATE
  • n-(3-alpha,7-alpha,12-alpha-trihydroxycholan-24-oyl)glycine
  • glycocholic acid free acid
  • GLYCOCHOLIC ACID HYDRAT
  • Clycocholic acid
  • Taurocholic aicd sodium salt
  • Cholylglycine, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, N-(3α,7α,12α-Trihydroxy-24-oxocholan-24-yl)-glycine
  • 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid n-(carboxymethyl)amide
  • 2-[4-(3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoylamino]acetic acid
  • N-cholyglycine
  • 3,7,12-Trihydroxy-5-cholan-24-oic acid 24-glycinamide
  • 2-[(3α,7α,12α-Trihydroxy-24-oxo-5β-cholane-24-yl)amino]acetic acid
  • Cholylglycinate
  • N-(3α,7α,12α-Trihydroxy-24-oxo-5β-cholan-24-yl)glycine
  • N-Carboxymethyl-3α,7α,12α-trihydroxy-5β-cholane-24-amide
  • N-(3α,7α,12α-Trihydroxy-24-oxocholan-24-yl)-glycine
  • Glycocholic acid hydrate,3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Cholylglycine, N-(3α,7α,12α-Trihydroxy-24-oxocholan-24-yl)-glycine
  • N-[(3α,5β,7α,12α)-3,7,12-Τrihydroxy-24-oxocholan-24-yl]glycine Hydrate
  • N-Choloylglycine
  • N-[(3α,5β,7α,12α)-3,7,12-Τrihydroxy-24-oxocholan-24-yl]glycine-d5
  • Glycocholic-d4 Acid
  • 2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)acetic acid
  • 2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)
  • 2-[[(4R)-1-oxo-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]amino]acetate
  • Ursodeoxycholic Impurity 11
  • Glycine, N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-
  • lycocholic acid
  • Glycocholic acid USP/EP/BP
  • ((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)glycine
  • GLYCOCHOLIC ACID HYDRATE
  • cholylglycine
  • [(3,7,12-Trihydroxy-24-oxocholan-24-yl)amino]acetic acid
  • N-Cholylglycine
  • GLYCITIN
  • glycocholicaci
  • Glycine, N-[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]-
  • Glycocholic Acid MaxSpec Standard
  • Urosodeoxycholic Acid Impurity 11
  • 5β-CHOLANIC ACID-3α, 7α, 12α-TRIOL N-(CARBOXYMETHYL)-AMIDE
  • Glyceric acid (medicinal excipients)
  • Glycocholate|||cholylglycine
  • 475-31-0
  • C26H45NO7
  • C26H43NO6xH2O
  • C26H43N06
  • C26H43NO6
  • C24H39O4NHCH2COOH
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