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475-31-0

中文名稱 甘氨膽酸
英文名稱 Glycocholic acid
CAS 475-31-0
EINECS 編號 207-494-9
分子式 C26H43NO6
MDL 編號 MFCD06408004
分子量 465.62
MOL 文件 475-31-0.mol
更新日期 2024/12/22 16:37:54
475-31-0 結構式 475-31-0 結構式

基本信息

中文別名
N-(3,7,12-三羥基-24-羰基膽烷-24-基)-甘氨酸
甘氨膽酸
3α,7α,12α-三羥基-5β-膽甾烷-24-羧酸-24-甘氨酰胺
N-[(3α,5β,7α,12α)-3,7,12-三羥基-24-氧代膽甾烷-24-基]甘氨酸
甘膽酸
甘膽酸水合物
甘膽酸
英文別名
3a,7a,12a-trihydroxy-5b-cholan-24-oic acid n-(carboxymethyl)amide
3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-[CARBOXYMETHYL]AMIDE
3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-(CARBOXYMETHYL) AMIDE, HYDRATE
5BETA-CHOLANIC ACID-3ALPHA,7ALPHA,12ALPHA-TRIOL 24-N-(CARBOXYMETHYL)-AMIDE
5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL N-(CARBOXYMETHYL)-AMIDE
cholylglycine
CHOLYLGLYCINE HYDRATE
GLYCOCHOLIC
GLYCOCHOLIC ACID
GLYCOCHOLIC ACID HYDRATE
N-[3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-24-OXOCHOLAN-24-YL]GLYCINE
N-(3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-24-OXOCHOLAN-24-YL)-GLYCINE HYDRATE
n-(3-alpha,7-alpha,12-alpha-trihydroxycholan-24-oyl)glycine
[(3,7,12-Trihydroxy-24-oxocholan-24-yl)amino]acetic acid
Glycine, N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]-
N-((3,5,7,12)-3,7,12-Trihydroxy-24-oxocholan-24-yl)glycine
N-Cholylglycine
glycocholic acid free acid
GLYCOCHOLIC ACID HYDRAT
Clycocholic acid
所屬類別
生物化工:中草藥成分

物理化學性質

外觀性狀倍半水合物為結晶(5%乙醇)。熔點130℃。[α]23/D+30.8°(C7.5 95%乙醇);無水結晶熔點165-168℃。微溶于水,遇酸堿分解成甘氨酸和膽酸。
熔點128°C
沸點568.76°C (rough estimate)
密度1.1336 (rough estimate)
折射率1.6000 (estimate)
儲存條件Refrigerator
溶解度methanol: 0.1 g/mL, clear, colorless
酸度系數(shù)(pKa)4.4(at 25℃)
形態(tài)固體
顏色白色至灰白色
水溶解性329.9mg/L(20 ºC)
Merck13,4507
穩(wěn)定性吸濕性
InChIKeyRFDAIACWWDREDC-NSPZZGDONA-N
LogP1.650
CAS 數(shù)據(jù)庫475-31-0(CAS DataBase Reference)
NIST化學物質信息Glycocholic acid(475-31-0)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302+H312+H332
防范說明P280
危險品標志N
危險類別碼R51/53
安全說明S61
危險品運輸編號UN 3077 9/PG 3
WGK Germany3

應用領域

用途一
去氫膽酸的中間體。

制備方法

方法一
可從膽汁或膽酸制取。

上下游產(chǎn)品信息

上游原料
膽酸
下游產(chǎn)品
去氫膽酸

常見問題列表

用途
甘氨膽酸可用作去氫膽酸的中間體,組要用于實驗室有機合成和化工醫(yī)藥研發(fā)過程,還可用于生化研究; 脂酶加速劑;陰離子去除劑,用于蛋白質的溶解。制備細菌培養(yǎng)基(腸道細菌培養(yǎng)與分離)。
生物活性
Glycocholic acid (Cholylglycine, Glycocholate) 是一種天然的次級膽汁酸,參與脂肪的乳化。
靶點

Human Endogenous Metabolite

體外研究

Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways.

知名試劑公司產(chǎn)品信息

甘氨膽酸價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/11XW04753102甘氨膽酸475-31-01G75元
2024/11/11XW04753101甘氨膽酸475-31-0250MG36元
2024/11/08HY-N1423甘氨膽酸
Glycocholic acid
475-31-050 mg350元
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