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3-Hydroxy-alpha-((methylamino)-methyl)benzolmethanol, (R)-

Phenylephrine Struktur
59-42-7
CAS-Nr.
59-42-7
Bezeichnung:
3-Hydroxy-alpha-((methylamino)-methyl)benzolmethanol, (R)-
Englisch Name:
Phenylephrine
Synonyma:
PHENYLEPHRINE BASE;Phenylephrin;L-PHENYLEPHRINE;(r)-phenylephrine;(-)-Phenylephrine Base;(R)-3-(1-Hydroxy-2-(methylamino)ethyl)phenol;C07441;Mesaton;Mezaton;Mydfrin
CBNumber:
CB0438096
Summenformel:
C9H13NO2
Molgewicht:
167.21
MOL-Datei:
59-42-7.mol

3-Hydroxy-alpha-((methylamino)-methyl)benzolmethanol, (R)- Eigenschaften

Schmelzpunkt:
171°C
Siedepunkt:
295.79°C (rough estimate)
Dichte
1.1222 (rough estimate)
Brechungsindex
-55.5 ° (C=5, 1mol/L HCl)
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
Slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides.
pka
pKa 8.9 (Uncertain)
Aggregatzustand
Solid
Farbe
White to Off-White
CAS Datenbank
59-42-7(CAS DataBase Reference)
NIST chemische Informationen
Benzenemethanol, 3-hydroxy-«alpha»-[(methylamino)methyl]-, (r)-(59-42-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36/37/38-41-37/38
S-S?tze: 26-36-45-39
RTECS-Nr. DO7175000
HS Code  2922.19.7000
Giftige Stoffe Daten 59-42-7(Hazardous Substances Data)
Toxizit?t LD50 oral in rat: 350mg/kg
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

3-Hydroxy-alpha-((methylamino)-methyl)benzolmethanol, (R)- Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

This synthetic drug has both chemical and pharmacological similarities to norepinephrine. A characteristic quality of phenylephrine is the distinctly expressed selectivity to α- adrenoreceptors, especially α1-adrenoreceptors. Although phenylephrine increases the contractibility of blood vessels, in practical terms it is not considered a cardiostimulant.

Chemische Eigenschaften

White or almost white, crystalline powder.

Verwenden

L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine. This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents. Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.

Definition

ChEBI: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.

Allgemeine Beschreibung

(Neo-Synephrine, a prototypical selectivedirect-acting 1-agonist) differs from E only inlacking a p-OH group. It is orally active, and its DOA isabout twice that of E because it lacks the catechol moietyand thus is not metabolized by COMT. However, its oralbioavailability is less than 10% because of its hydrophilicproperties (log P=0.3), intestinal 3 -O-glucuronidation/sulfation and metabolism by MAO. Lacking the p-OHgroup, it is less potent than E and NE but it is a selectiveα1-agonist and thus a potent vasoconstrictor. It is usedsimilarly to metaraminol and methoxamine for hypotension.Another use is in the treatment of severe hypotensionresulting from either shock or drug administration. It alsohas widespread use as a nonprescription nasal decongestantin both oral and topical preparations. When applied tomucous membranes, it reduces congestion and swelling byconstricting the blood vessels of the membranes. In theeye, it is used to dilate the pupil and to treat open-angleglaucoma. In addition, it is used in spinal anesthesia toprolong the anesthesia and to prevent a drop in blood pressureduring the procedure. It is relatively nontoxic and produceslittle CNS stimulation. Metaraminol is just anotherexample.

Clinical Use

Phenylephrine is a potent direct-acting α1-agonist with clinical effects similar to those of noradrenaline. It causes widespread vasoconstriction with an increase in arterial pressure, reflex bradycardia and decrease in cardiac output. It may be administered by i.v. bolus (50–100μg boluses) and i.v. infusion (50–150μgmin –1) to maintain arterial pressure during general anaesthesia or other causes of low SVR. It may also be used topically as a nasal decongestant or mydriatic. There is some evidence suggesting a paradoxical reduction in cerebral oxygen delivery.

Sicherheitsprofil

Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intraduodenal routes. Human systemic effects by ocular route: blood pressure increase. An experimental teratogen. Other experimental reproductive effects. A nasal decongestant. When heated to decomposition it emits toxic fumes of NOx.

3-Hydroxy-alpha-((methylamino)-methyl)benzolmethanol, (R)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-Hydroxy-alpha-((methylamino)-methyl)benzolmethanol, (R)- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 202)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Worldyang Chemical Co.,Ltd.
+86-021-56795779 +8613651600618
sales@worldyachem.com China 1243 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004
1015@dideu.com China 3942 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Alfa Chemistry

info@alfa-chemistry.com United States 2344 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665
dominicguo@gk-bio.com CHINA 9414 58

59-42-7(3-Hydroxy-alpha-((methylamino)-methyl)benzolmethanol, (R)-)Verwandte Suche:


  • component of Dristan cold
  • component of Dristan nasal mist
  • component of Entex
  • component of Histalet forte
  • component of Hycomine compound
  • component of Prefrin-a
  • component of Pv tussin syrup
  • component of Relief
  • (-)-PHENYLEPHRINE
  • (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
  • component of Ru-tuss liquid
  • component of Ru-tuss tablets
  • component of Vasosulf
  • component of Zincfrin
  • Isophrin
  • l-(3-Hydroxyphenyl)-N-methylethanolamine
  • l-1-(m-Hydroxyphenyl)-2-methylaminoethanol
  • l-alpha-Hydroxy-beta-methylamino-3-hydroxy-l-ethylbenzene
  • l-m-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol
  • l-m-hydroxy-alpha-((methylamino)methyl)benzylalcohol
  • Mesaton
  • Mesatone
  • Metaoxedrin
  • Metaoxedrine
  • Metasympatol
  • Metasynephrine
  • Mezaton
  • m-Methylaminoethanolphenol
  • m-Oxedrine
  • m-Sympathol
  • m-Sympatol
  • m-Synephrine
  • Mydfrin
  • Neophryn
  • Neosynephrine
  • Nostril
  • Prefrin
  • Pyracort D
  • R(-)-Mezaton
  • R(-)-Phenylephrine
  • Visadron
  • 3-(1-HYDROXY-2-METHYLAMINO-ETHYL)PHENOL
  • 7: PN: US20030109453 SEQID: 6 claimed sequence
  • Benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, (aR)- (9CI)
  • Benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, (R)-
  • l-m-Hydroxy-a-[(methylamino)methyl]benzyl alcohol
  • L-Phenylephedrine
  • Phenylephrine (base and/or unspecified salts)
  • 3-Hydroxy-alpha-((methylamino)methyl)-benzyl alcohol
  • α-[(Methylamino)methyl]-3-hydroxybenzenemethanol
  • (-)-1-(3-hydroxyphenyl)-2-methylaminoethanol
  • C07441
  • BenzeneMethanol,3-hydroxy-a-[(MethylaMino)Methyl]-, (aR)-
  • L-Phenylephrine
  • R-(γ)-Phe
  • PHARMA CHEMICAL PHENYLEPHRINE HCL
  • (-)-m-hydroxy-alpha-(methylaminomethyl)benzylalcohol
  • (-)-m-oxedrine
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