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Procarbazin

Isopropyl-α-[2-methylhydrazino]-p-toluamide Struktur
671-16-9
CAS-Nr.
671-16-9
Bezeichnung:
Procarbazin
Englisch Name:
Isopropyl-α-[2-methylhydrazino]-p-toluamide
Synonyma:
pcx;MIH;Natulan;natulane;RO 4-6467;cb400-497;Nathulane;Natulanar;Ro 4-6467/1;Procarbazin
CBNumber:
CB4185420
Summenformel:
C12H19N3O
Molgewicht:
221.3
MOL-Datei:
671-16-9.mol

Procarbazin Eigenschaften

Siedepunkt:
362.36°C (rough estimate)
Dichte
1.0490 (rough estimate)
Brechungsindex
1.5290 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka
pKa 6.8(H2O,I=0.1) (Uncertain)
CAS Datenbank
671-16-9(CAS DataBase Reference)
NIST chemische Informationen
Benzamide, n-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-(671-16-9)
EPA chemische Informationen
Procarbazine (671-16-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Giftige Stoffe Daten 671-16-9(Hazardous Substances Data)
Toxizit?t A substituted hydrazine developed and used as an antineoplastic agent. It has been found to be carcinogenic in several species, the mechanism being, presumably and by analogy with 1,2-dimethyl hydrazine, the release of the methyl carbonium ion. This compound is also known to be immunosuppressive and to have adverse effects on the reproductive system.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Procarbazin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Procarbazine is a white to pale yellow crystal- line powder with a slight odor.

Verwenden

antibacterial

Definition

ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procar azine and hydrogen peroxide, which results in the breaking of DNA strands.

Indications

Procarbazine (Matulane) may autooxidize spontaneously, and during this reaction hydrogen peroxide and hydroxyl free radicals are generated. These highly reactive products may degrade DNA and serve as one mechanism of procarbazine-induced cytotoxicity. Cell toxicity also may be the result of a transmethylation reaction that can occur between the N-methyl group of procarbazine and the N7 position of guanine.

Mechanism of action

Procarbazine is rapidly absorbed after oral administration and has a plasma half-life of only 10 minutes. The drug crosses the blood-brain barrier, reaching levels in CSF equal to those obtained in plasma. Metabolism is extensive and complex. Urinary excretion accounts for 70% of the procarbazine and its metabolites lost during the first 24 hours after drug administration.

Clinical Use

When originally tested as a single agent in advanced Hodgkin’s disease, procarbazine produced tumor regression responses that were brief, usually lasting only 1 to 3 months. The combination of procarbazine with mechlorethamine, vincristine, and prednisone in the MOPP regimen, however, resulted in an 81% complete remission rate in Hodgkin’s disease. Most of these patients are considered cured. Procarbazine is also used in various combination chemotherapy protocols for non- Hodgkin’s lymphomas and small cell anaplastic (oat cell) carcinoma of the lung. Limited antitumor effects have been observed against multiple myeloma, melanoma, and non–oat cell lung cancers.

Nebenwirkungen

The major side effects associated with procarbazine therapy are nausea and vomiting, leukopenia, and thrombocytopenia. Skin rashes have been reported, as have rare cases of allergic interstitial pneumonia. Procarbazine administration produces a high degree of chromosomal breakage, and the compound is mutagenic, teratogenic, and carcinogenic in experimental systems.
Procarbazine may potentiate the effects of tranquilizers and hypnotics. Hypertensive episodes can result if procarbazine is administered simultaneously with adrenomimetic drugs or with tyramine-containing foods. Rarely, a reaction to alcohol similar to that provoked by disulfiram may occur.

m?gliche Exposition

Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.

Carcinogenicity

Procarbazine and procarbazine hydrochloride are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. The names “procarbazine” and “procarbazine hydrochloride” are used interchangeably in published studies; because only procarbazine hydrochloride is produced, it has been assumed that procarbazine hydrochloride was the substance under study.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Inkompatibilit?ten

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Procarbazin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Procarbazin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 75)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2524 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32002 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34553 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15361 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665
dominicguo@gk-bio.com CHINA 9414 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
+8617731987558
xingjiu@xingjiubiotech.com China 989 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18275 58

671-16-9(Procarbazin)Verwandte Suche:


  • natulane
  • Isopropyl-α-[2-methylhydrazino]-p-toluamide
  • Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-
  • Ro 4-6467/1
  • PROCARBAZINE
  • n-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide
  • 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
  • 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine
  • 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide
  • Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-
  • p-(2-methylhydrazinomethyl)-n-isopropylbenzamide
  • p-(n’-methylhydrazinomethyl)-n-isopropylbenzamide
  • PCB hydrochloride
  • pcx
  • Procarbazin
  • p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-
  • RO 4-6467
  • n-(1-Methylethyl)-4
  • N-(3-Isopropylideneacetonyl)-4-pyridinecarbohydrazonic acid
  • N-Isopropyl-α-(2-methylhydrazino)-p-toluamide
  • N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide
  • N-Isopropyl-4-((2-methylhydrazinyl)
  • cb400-497
  • ibenzmethyzin
  • Ibenzmethyzine
  • MIH
  • MIH hydrochloride
  • n-(1-methylethyl)-4-((2-methylhydrazino)methyl)-benzamid
  • n-(1-methylethyl)-4-((2-methylhydrazino)methyl-benzamid
  • n-4-isopropylcarbamoylbenzyl-n’-methylhydrazine
  • Nathulane
  • Natulan
  • Natulanar
  • N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide
  • n-isopropyl-alpha-(2-methylhydrazino)-p-toluamid
  • N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide
  • Procarbazine USP/EP/BP
  • Isopropyl-α-[2-methylhydrazino]-p-toluamide
  • Procarbazine free base
  • 671-16-9
  • C12H19N3O
  • Active Pharmaceutical Ingredients
  • CEFZIL
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