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N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid

Procarbazine hydrochloride  Struktur
366-70-1
CAS-Nr.
366-70-1
Bezeichnung:
N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid
Englisch Name:
Procarbazine hydrochloride
Synonyma:
PROCARBAZINE HCL;matulane;ibz;Mutulane;nsc-77213;nci-c01810;NSC-77213 HCl;natulanhydrochloride;ibenzmethyzinhydrochloride;PROCARBAZINE HYDROCHLORIDE
CBNumber:
CB6678902
Summenformel:
C12H20ClN3O
Molgewicht:
257.76
MOL-Datei:
366-70-1.mol

N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid Eigenschaften

Schmelzpunkt:
223°C
Dichte
8.3 g/cm3
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
DMSO: ≥18mg/mL
Aggregatzustand
powder
Farbe
white to tan
Wasserl?slichkeit
>=10 g/100 mL at 21.5 ºC
Merck 
14,7758
BCS Class
3/1
CAS Datenbank
366-70-1(CAS DataBase Reference)
IARC
2A (Vol. 26, Sup 7) 1987
EPA chemische Informationen
Procarbazine hydrochloride (366-70-1)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 45-61-22-68
S-S?tze: 53-36/37-45
WGK Germany  3
RTECS-Nr. XS4725000
HS Code  2928002500
Toxizit?t LD50 orally in rats: 785 ±34 mg/kg (Goldenthal)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H341 Kann vermutlich genetische Defekte verursachen. Keimzellmutagenit?t Kategorie 2 Warnung P201,P202, P281, P308+P313, P405,P501
H350 Kann Krebs verursachen. Karzinogenit?t Kategorie 1A Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Crystalline Solid

Verwenden

Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.

Definition

ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.

Allgemeine Beschreibung

White to pale yellow crystalline powder with a slight odor. Acid to litmus.

Air & Water Reaktionen

In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.

Reaktivit?t anzeigen

Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .

Brandgefahr

Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.

m?gliche Exposition

Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Inkompatibilit?ten

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 187)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3959 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

366-70-1(N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid)Verwandte Suche:


  • N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-benzamide,hydrochloride (1:1)
  • NSC-77213 HCl
  • N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride
  • Procarbazine hydrochloride, >=99%
  • Procarbazine hydrochloride (Matulane)
  • ibenzmethyzinhydrochloride
  • ibz
  • n-(1-methylethyl)-4-((2-methylhydrazino)methyl)-benzamidmonohydrochlorid
  • natulanhydrochloride
  • nci-c01810
  • n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidehydrochloride
  • 1-(p-isopropylcarbamoylbenzyl)-2-methylhydrazinehydrochloride
  • 1-methyl-2-(p-isopropylcarbamoylbenzyl)hydrazinehydrochloride
  • 1-methyl-2-p-(isopropylcarbamyol)benzohydrazinehydrochloride
  • 2-(p-(isopropylcarbamoyl)benzyl)-1-methylhydrazinehydrochloride
  • chlorhydratede1-methyl2p(isopropylcarbamoyl)benzyl-hydrazine
  • ibenzmethyzinehydrochloride
  • n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidhydrochloride
  • n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidmonohydrochloride
  • n-isopropyl-p-(2-methylhydrazinomethyl)benzamidehydrochloride
  • nsc-77213
  • p-(n’-methylhydrazinomethyl)-n-isopropylbenzamidehydrochloride
  • PROCARBAZINE HYDROCHLORIDE
  • Mutulane
  • N-Isopropyl-(2-methylhydrazino)-p-toluamide-Hydrochloride
  • N-ISOPROPYL-ALPHA-(2-METHYLHYDRAZINO)-PARA-TOLUAMIDE
  • n-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride
  • Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride
  • Procarbazine hydrochloride ,98%
  • Procarbazine Hydrochloride (200 mg)
  • 4-[(methylhydrazo)methyl]-N-propan-2-ylbenzamide hydrochloride
  • N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride
  • N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide hydrochloride
  • Procarbazine HCl (NSC-77213)
  • TIANFU CHEM---Procarbazine hydrochloride
  • Procarbazine Hydrochloride (1565009)
  • matulane
  • PROCARBAZINE HCL
  • 366-70-1
  • 156-2-23
  • C12H19N3OClH
  • C12H20ClN3O
  • C12H19N3OHCl
  • API
  • Matulane
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 366-70-1
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