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Isoprenalinhydrochlorid

Isoprenaline hydrochloride  Struktur
51-30-9
CAS-Nr.
51-30-9
Bezeichnung:
Isoprenalinhydrochlorid
Englisch Name:
Isoprenaline hydrochloride
Synonyma:
ISOPRENALINE HCL;ISOPROTERENOL HYDROCHLORIDE;isuprel;Isovon;Isomenyl;Mistarel;euspiran;isadrine;Proterno;proternol
CBNumber:
CB5276844
Summenformel:
C11H18ClNO3
Molgewicht:
247.72
MOL-Datei:
51-30-9.mol

Isoprenalinhydrochlorid Eigenschaften

Schmelzpunkt:
165-175 °C (dec.)(lit.)
Siedepunkt:
192°C (rough estimate)
Dichte
1.2296 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
2-8°C
L?slichkeit
Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Aggregatzustand
White solid
Farbe
White to Off-White
Wasserl?slichkeit
Soluble
BRN 
3917363
Stabilit?t:
Stable, but may be air and light sensitive. Incompatible with strong oxidizing agents.
InChI
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
InChIKey
IROWCYIEJAOFOW-UHFFFAOYSA-N
SMILES
C1(=CC=C(O)C(O)=C1)C(O)CNC(C)C.Cl
CAS Datenbank
51-30-9(CAS DataBase Reference)
EPA chemische Informationen
Isoproterenol hydrochloride (51-30-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  2
RTECS-Nr. DO1925000
3-8-10
HS Code  29225090
Toxizit?t LD50 oral in rabbit: 3070mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Isoprenalinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Isoprenaline hydrochloride is an FDA-approved injectable drug that is the hydrochloride form of isoprenaline and is used as a bronchodilator, adrenergic beta agonist, cardiotonic, and sympathomimetic. Selective beta-adrenergic agonist that increases cytoplasmic cAMP. promotes glycogenolysis and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit tracheal cells via nitric oxide production. In addition, it can be used as an inducer in an experimental rat model of induced myocardial infarction[1].

Chemische Eigenschaften

White or almost white, crystalline powder.

Verwenden

Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.

Allgemeine Beschreibung

Odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air.

Air & Water Reaktionen

May be sensitive to exposure to air and light. . Water soluble.

Reaktivit?t anzeigen

An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Health Hazard

SYMPTOMS: Symptoms of exposure to Isoprenaline hydrochloride may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating.

Brandgefahr

Flash point data for Isoprenaline hydrochloride are not available. Isoprenaline hydrochloride is probably combustible.

Biologische Aktivit?t

Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ .

Einzelnachweise

[1] FANG WANG. Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats[J]. Pharmacognosy Magazine, 2020, 16 1: 214-220. DOI:10.4103/pm.pm\_357\_19.

Isoprenalinhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Isoprenalinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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51-30-9(Isoprenalinhydrochlorid)Verwandte Suche:


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