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Isoprenalin

Isoproterenol Struktur
7683-59-2
CAS-Nr.
7683-59-2
Bezeichnung:
Isoprenalin
Englisch Name:
Isoproterenol
Synonyma:
isoprenaline;A 21;isoprel;Aludrin;asmalar;Aludrine;NSC 9975;Lomupren;Aleudrine;ICI 46399
CBNumber:
CB3854910
Summenformel:
C11H17NO3
Molgewicht:
211.26
MOL-Datei:
7683-59-2.mol

Isoprenalin Eigenschaften

Schmelzpunkt:
170.5°C
Siedepunkt:
350.94°C (rough estimate)
Dichte
1.1240 (rough estimate)
Brechungsindex
1.5718 (estimate)
pka
8.64(at 25℃)
NIST chemische Informationen
3,4-Dihydroxy-«alpha»-(isopropylaminomethyl)-benzyl alcohol(7683-59-2)

Sicherheit

Isoprenalin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Isoproterenol is a representative of the sympathomimetic drugs with high selectivity to β- adrenoreceptors. As was already noted, the addition to compounds of a bulky iso-propyl or tert-butyl group at the nitrogen atom of the β-phenylethylamino skeleton is associated with higher affinity to β-adrenergic receptive regions than to α-adrenergic. Isoproterenol is devoid of significant α-adrenergic agonistic action. Activation of β1-adrenergic receptors in the heart increases positive chronotropic and ionotropic action. Peripheral vascular resistance is increased by the widening of blood vessels, primarily in skeletal muscle, but also in renal and mesenteric blood circulation, which is caused by the β2-adrenergic system.

Verwenden

Isoproterenol is used in bronchospasms, asthma, cardiac block, and shock.

Definition

ChEBI: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hy rochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Indications

Isoproterenol is administered almost exclusively by inhalation from metered-dose inhalers or from nebulizers. The response to inhaled isoproterenol and other inhaled adrenomimetics is instantaneous. The action of isoproterenol is short-lived, although an objective measurement of pulmonary function has shown an effective duration of up to 3 hours. When it is administered by inhalation, the cardiac effects of isoproterenol are relatively mild, although in some cases a substantial increase in heart rate occurs.

Weltgesundheitsorganisation (WHO)

Isoprenaline, a beta-adrenoreceptor agonist, was introduced in 1949 as treatment for a number of cardiac disorders and as a bronchial dilator for the symptomatic treatment of asthma. There is evidence that regular inhalation of bronchodilator drugs is associated, in some cases with exacerbation of the disease and with increased fatality rates. The underlying causes are disputed, but an increasing body of opinion now advocates regular maintenance therapy with inhaled, corticosteroids coupled with supplementary use as required of bronchial drugs to suppress exacerbations.

Allgemeine Beschreibung

Isoproterenol is a nonselective and prototypical -agonist ( β2/ β1=1). After oral administration,the absorption of ISO is rather erratic and undependable.The principal reason for its poor absorption characteristicsand relatively short DOA is its facile metabolism by sulfateand glucuronide conjugation of the phenolic OH groupsand O-methylation by COMT. Because it is a catechol, it issensitive to light and air. Aqueous solutions become pinkon standing. Unlike E and NE, ISO does not appear to undergo oxidative deamination by MAO. The drug hasDOA of 1 to 3 hours after inhalation.

Clinical Use

Isoproterenol is used principally by inhalation for the management of bronchospasm. It is also used intravenously for asthma and as a stimulant in cardiac arrest.

Sicherheitsprofil

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by intramuscular route: increased pulse and cardac rate. A bronchodilator. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx

Isoprenalin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Isoprenalin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 58)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338
stella@zetchem.com China 2136 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 31991 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34553 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15361 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
+8617731987558
xingjiu@xingjiubiotech.com China 989 58
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 2994 58
sgtlifesciences pvt ltd
+8617013299288
dj@sgtlifesciences.com China 12373 58

7683-59-2(Isoprenalin)Verwandte Suche:


  • 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
  • isoproterenol
  • 4-(1-hydroxy-2-(isopropylaMino)ethyl)benzene-1,2-diol
  • isoprel
  • saventrine
  • Isoproterenol (base and/or unspecified salts)
  • 4-(2-Isopropylamino-1-hydroxyethyl)-1,2-benzenediol
  • 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol
  • Aludrine
  • .alpha.-(Isopropylaminomoethyl)protocatechuyl alcohol
  • A 21
  • Aleudrine
  • Aludrin
  • Isoproterenol Isoproterenol Hydrochloride
  • 1,2-Benzenediol, 4-1-hydroxy-2-(1-methylethyl)aminoethyl-
  • 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- (9CI)
  • dl-Isadrine
  • dl-Isoprenaline
  • dl-Isopropylnoradrenaline
  • DL-Isopropylnorepinephrine
  • dl-N-Isopropylnoradrenaline
  • Epinephrine isopropyl homolog
  • ICI 46399
  • NSC 33791
  • NSC 9975
  • Racemic isoprenaline
  • Racemic isoproterenol
  • Respifral
  • Vapo-N-Iso
  • 1-(3,4-dihydroxyphenyl)-2-isopropylaminoethanol
  • 3,4-dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol
  • 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol
  • alpha-(isopropylaminomethyl)protocatechuyl alcohol
  • asiprenol
  • asmalar
  • assiprenol
  • bellasthman
  • dihydroxyphenylethanolisopropylamine
  • Isoproterenol USP/EP/BP
  • (RS)-4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol
  • isoprenaline
  • Lomupren
  • 7683-59-2
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