58691-88-6
中文名稱
諾美孕酮
英文名稱
Nomegestrol
CAS
58691-88-6
分子式
C21H28O3
分子量
328.45
MOL 文件
58691-88-6.mol
更新日期
2024/10/28 10:45:17
58691-88-6 結(jié)構(gòu)式
基本信息
中文別名
諾美孕酮 英文別名
MonacoTherMex
Nomegestrel
Nomegestrol
NOMEGESTROL ACETATE
MELEGESTROL ACETATE
Nomegestrol USP/EP/BP
Nomegestrol###58691-88-6
17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione
所屬類別
原料藥：雌激素及孕激素類藥物理化學(xué)性質(zhì)
沸點(diǎn)502.6±50.0 °C(Predicted)
密度1.17±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度Chloroform: soluble,DMSO: slightly soluble,Methanol: slightly soluble
酸度系數(shù)(pKa)12.99±0.60(Predicted)
形態(tài)固體
常見問題列表
生物活性
Nomegestrol 是一種有效的，可口服的孕酮，為選擇性的孕酮受體 (progesterone receptor) 完全激動(dòng)劑，對(duì)大鼠子宮孕酮受體的 Kd 值為 5.44 nM，具有很強(qiáng)的抗雌性激素活性，適度的抗雄性激素活性。靶點(diǎn)
Kd: 5.44 nM (Rat uterine progesterone receptor)
體外研究
Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a K d of 5.44 nM for rat uterine progesterone receptor. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity.