1197376-85-4
中文名稱
卡馬替尼鹽酸鹽
英文名稱
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride
CAS
1197376-85-4
分子式
C23H19Cl2FN6O
分子量
485.341
MOL 文件
1197376-85-4.mol
更新日期
2024/12/19 09:40:05
1197376-85-4 結(jié)構(gòu)式
基本信息
中文別名
卡馬替尼鹽酸鹽苯扎米特鹽酸鹽
卡馬替尼二鹽酸鹽
INCB28060鹽酸鹽
苯扎米特INCB28060鹽酸鹽
卡馬替尼(INC28060鹽酸鹽)
2-氟-N-甲基-4-[7-[(喹啉-6-基)甲基]咪唑并[1,2-B]-[1,2,4]三嗪-2-基]苯甲酰胺二鹽酸鹽
英文別名
INC-280 2HClINCB28060 2HCl
Capmatinib 2HCl
INCB28060 Dihydrochloride
Capmatinib Dihydrochloride
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride
所屬類別
有機(jī)原料：羧酸類化合物及衍生物
應(yīng)用領(lǐng)域
用途一
INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.