2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
- $32 - $9606
- Product name: 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
- CAS: 1173900-33-8
- MF: C22H24N4O4
- MW: 408.45
- EINECS:-0
- MDL Number:MFCD16659062
- Synonyms:2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid;AZD 6482;AZD6482(PI3-kinase β inhibitor);AZD-6482/AZD6482;AZD6482(r);(R)AZD64822-[[(1R)-1-[7-Methyl-2-(4-Morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyriMidin-9-yl]ethyl]aMino]benzoic acid;KIN-193;2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid AZD 6482
31 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 50
- 1MG
- 10mg
- 25mg
- 50mg
- 100mg
- 10
- 1g
- ManufacturerAK Scientific
- Product number2243AH
- Product description2-[[(1R)-1-(7-Methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoicacid
- Packaging1g
- Price$9606
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA560000
- Product descriptionAzd6482 98+%
- Packaging10mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA560000
- Product descriptionAzd6482 98+%
- Packaging50mg
- Price$422
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA560000
- Product descriptionAzd6482 98+%
- Packaging100mg
- Price$549
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000923
- Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
- Packaging1MG
- Price$148.05
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000923
- Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
- Packaging10MG
- Price$1006.58
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000923
- Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
- Packaging50MG
- Price$1734.23
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000923
- Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
- Packaging1G
- Price$8101.17
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5478
- Product descriptionAZD6482
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60266
- Product descriptionAZD6482
- Packaging10mg
- Price$378
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2926
- Product descriptionAZD6482-KIN-193 99%
- Packaging5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2926
- Product descriptionAZD6482-KIN-193 99%
- Packaging25mg
- Price$462
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA137652
- Product descriptionAZD 6482
- Packaging10mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA137652
- Product descriptionAZD 6482
- Packaging50mg
- Price$857.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15250
- Product descriptionAZD6482 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15250
- Product descriptionAZD6482 ≥98%
- Packaging5mg
- Price$131
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 2243AH | 2-[[(1R)-1-(7-Methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoicacid | 1g | $9606 | 2021-12-16 | Buy |
Ambeed | A560000 | Azd6482 98+% | 10mg | $126 | 2021-12-16 | Buy |
Ambeed | A560000 | Azd6482 98+% | 50mg | $422 | 2021-12-16 | Buy |
Ambeed | A560000 | Azd6482 98+% | 100mg | $549 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000923 | (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% | 1MG | $148.05 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000923 | (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% | 10MG | $1006.58 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000923 | (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% | 50MG | $1734.23 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000923 | (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% | 1G | $8101.17 | 2021-12-16 | Buy |
ApexBio Technology | A5478 | AZD6482 | 25mg | $360 | 2021-12-16 | Buy |
Arctom | CFN60266 | AZD6482 | 10mg | $378 | 2021-12-16 | Buy |
Axon Medchem | Axon2926 | AZD6482-KIN-193 99% | 5mg | $132 | 2021-12-16 | Buy |
Axon Medchem | Axon2926 | AZD6482-KIN-193 99% | 25mg | $462 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA137652 | AZD 6482 | 10mg | $245 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA137652 | AZD 6482 | 50mg | $857.5 | 2021-12-16 | Buy |
Cayman Chemical | 15250 | AZD6482 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 15250 | AZD6482 ≥98% | 5mg | $131 | 2024-03-01 | Buy |
Properties
Boiling point :635.5±65.0 °C(Predicted)
Density :1.36
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥20.4 mg/mL in DMSO; ≥6.36 mg/mL in EtOH
form :solid
pka :3.90±0.50(Predicted)
color :White to light yellow
Density :1.36
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥20.4 mg/mL in DMSO; ≥6.36 mg/mL in EtOH
form :solid
pka :3.90±0.50(Predicted)
color :White to light yellow
Safety Information
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Description
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. AZD6482 is a PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC50s = 0.69, 13.6, 47.8, and 136 nM, respectively). It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases. AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss. AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice. It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss.More related product prices
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- 1217486-61-7 GSK2636771 ABT-199 MK-2206 2HCl BKM120 (NVP-BKM120, Buparlisib) BMS-794833 371942-69-7 356559-20-1 675576-98-4 R428 Tozasertib NVP-BVU 972 ARRY-424704, ARRY-704 Binimetinib ChlorotrimethylsilaneRelated product price
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Suppliers and manufacturers
career henan chemical co
Capot Chemical Co.,Ltd.
Biochempartner
Hubei Jusheng Technology Co.,Ltd.
Chongqing Chemdad Co., Ltd
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
$1.00 /1KG
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid CAS:1173900-33-8
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid CAS:1173900-33-8