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ChemicalBook >> CAS DataBase List >> 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid

2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid

2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid price.
  • $32 - $9606
  • Product name: 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
  • CAS: 1173900-33-8
  • MF: C22H24N4O4
  • MW: 408.45
  • EINECS:-0
  • MDL Number:MFCD16659062
  • Synonyms:2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid;AZD 6482;AZD6482(PI3-kinase β inhibitor);AZD-6482/AZD6482;AZD6482(r);(R)AZD64822-[[(1R)-1-[7-Methyl-2-(4-Morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyriMidin-9-yl]ethyl]aMino]benzoic acid;KIN-193;2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid AZD 6482
31 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 50
  • 1MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 10
  • 1g
  • ManufacturerAK Scientific
  • Product number2243AH
  • Product description2-[[(1R)-1-(7-Methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoicacid
  • Packaging1g
  • Price$9606
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA560000
  • Product descriptionAzd6482 98+%
  • Packaging10mg
  • Price$126
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA560000
  • Product descriptionAzd6482 98+%
  • Packaging50mg
  • Price$422
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA560000
  • Product descriptionAzd6482 98+%
  • Packaging100mg
  • Price$549
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000923
  • Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
  • Packaging1MG
  • Price$148.05
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000923
  • Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
  • Packaging10MG
  • Price$1006.58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000923
  • Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
  • Packaging50MG
  • Price$1734.23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000923
  • Product description(R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00%
  • Packaging1G
  • Price$8101.17
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5478
  • Product descriptionAZD6482
  • Packaging25mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60266
  • Product descriptionAZD6482
  • Packaging10mg
  • Price$378
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2926
  • Product descriptionAZD6482-KIN-193 99%
  • Packaging5mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2926
  • Product descriptionAZD6482-KIN-193 99%
  • Packaging25mg
  • Price$462
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137652
  • Product descriptionAZD 6482
  • Packaging10mg
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137652
  • Product descriptionAZD 6482
  • Packaging50mg
  • Price$857.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15250
  • Product descriptionAZD6482 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15250
  • Product descriptionAZD6482 ≥98%
  • Packaging5mg
  • Price$131
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2243AH 2-[[(1R)-1-(7-Methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoicacid 1g $9606 2021-12-16 Buy
Ambeed A560000 Azd6482 98+% 10mg $126 2021-12-16 Buy
Ambeed A560000 Azd6482 98+% 50mg $422 2021-12-16 Buy
Ambeed A560000 Azd6482 98+% 100mg $549 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000923 (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% 1MG $148.05 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000923 (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% 10MG $1006.58 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000923 (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% 50MG $1734.23 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000923 (R)-2-(1-(7-METHYL-2-MORPHOLINO-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO)BENZOIC ACID 95.00% 1G $8101.17 2021-12-16 Buy
ApexBio Technology A5478 AZD6482 25mg $360 2021-12-16 Buy
Arctom CFN60266 AZD6482 10mg $378 2021-12-16 Buy
Axon Medchem Axon2926 AZD6482-KIN-193 99% 5mg $132 2021-12-16 Buy
Axon Medchem Axon2926 AZD6482-KIN-193 99% 25mg $462 2021-12-16 Buy
Biosynth Carbosynth FA137652 AZD 6482 10mg $245 2021-12-16 Buy
Biosynth Carbosynth FA137652 AZD 6482 50mg $857.5 2021-12-16 Buy
Cayman Chemical 15250 AZD6482 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 15250 AZD6482 ≥98% 5mg $131 2024-03-01 Buy

Properties

Boiling point :635.5±65.0 °C(Predicted)
Density :1.36
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥20.4 mg/mL in DMSO; ≥6.36 mg/mL in EtOH
form :solid
pka :3.90±0.50(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. AZD6482 is a PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC50s = 0.69, 13.6, 47.8, and 136 nM, respectively). It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases. AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss. AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice. It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss.