| Identification | Back Directory | [Name]
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid | [CAS]
1173900-33-8 | [Synonyms]
S1462
KIN-193
AZD 6482
AZD6482(r)
AZD6482, >=98%
AZD-6482/AZD6482
AZD 6482 - KIN-193
AZD6482; AZD-6482; AZD 6482.
AZD6482(PI3-kinase β inhibitor)
AZD 6482, 98%, a PI3Kβ inhibitor
(R)-2-(1-(7-Methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid
2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoi
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
Benzoic acid, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid USP/EP/BP
(R)AZD64822-[[(1R)-1-[7-Methyl-2-(4-Morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyriMidin-9-yl]ethyl]aMino]benzoic acid
2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid AZD 6482 | [Molecular Formula]
C22H24N4O4 | [MDL Number]
MFCD16659062 | [MOL File]
1173900-33-8.mol | [Molecular Weight]
408.45 |
| Chemical Properties | Back Directory | [Boiling point ]
635.5±65.0 °C(Predicted) | [density ]
1.36 | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥20.4 mg/mL in DMSO; ≥6.36 mg/mL in EtOH | [form ]
solid | [pka]
3.90±0.50(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid is a pyridopyrimidine. | [Biological Activity]
azd6428 is a potent, selective and atp-competitive pi3kβ inhibitor. ic50 are 0.69, 13.6, 47.8 and 136 nm for pi 3-kβ, pi 3-kδ, pi 3-kγ and pi 3-kα, respectively.pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway. | [in vitro]
azd6482 inhibited insulin-activated uptake of human adpocyte glucose (ic50=4.4 μm). a full anti-thrombotic response with no increased bleeding or blood loss was observed in dog treated with azd6482 in vivo. it also showed good tolerance in a three-hour azd6482 infusion in healthy volunteers. there was an approx.10-20% rise at 5.3 μm (highest plasma concentration) according to the homeostasis model analysis index. [1] | [storage]
Store at -20°C | [References]
nylander s, kull b, bj?rkman ja et al. human target validation of phosphoinositide 3-kinase (pi3k)β: effects on platelets and insulin sensitivity, using azd6482 a novel pi3kβ inhibitor. j thromb haemost. 2012 oct;10(10):2127-36. |
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