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ChemicalBook >> CAS DataBase List >> 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide price.
  • $39 - $2691.1
  • Product name: 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide
  • CAS: 371942-69-7
  • MF: C25H21N7O3
  • MW: 467.48
  • EINECS:
  • MDL Number:MFCD16038303
  • Synonyms:6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM201636;YM 201636 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide;YM201636, >=98%;YM201636 HCl;6-amino-N-(3-(4-morpholinopyrido[3,,2,:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)nicotinamide;3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-;6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide;YM 201636
34 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 2mg
  • 5MG
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberY0272
  • Product descriptionYM201636
  • Packaging1mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000632
  • Product descriptionYM 201636 95.00%
  • Packaging1MG
  • Price$476
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000632
  • Product descriptionYM 201636 95.00%
  • Packaging5MG
  • Price$811.86
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000632
  • Product descriptionYM 201636 95.00%
  • Packaging25MG
  • Price$1437.11
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2189
  • Product descriptionYM201636
  • Packaging5mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2189
  • Product descriptionYM201636
  • Packaging10mM(in 1mL DMSO)
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2189
  • Product descriptionYM201636
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2189
  • Product descriptionYM201636
  • Packaging50mg
  • Price$645
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2189
  • Product descriptionYM201636
  • Packaging100mg
  • Price$1100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181182
  • Product descriptionYM201636 >98%
  • Packaging100mg
  • Price$578
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181182
  • Product descriptionYM201636 >98%
  • Packaging250mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181182
  • Product descriptionYM201636 >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137438
  • Product description6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137438
  • Product description6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide
  • Packaging2mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137438
  • Product description6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide
  • Packaging5mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137438
  • Product description6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide
  • Packaging10mg
  • Price$350
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0272 YM201636 1mg $39 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000632 YM 201636 95.00% 1MG $476 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000632 YM 201636 95.00% 5MG $811.86 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000632 YM 201636 95.00% 25MG $1437.11 2021-12-16 Buy
ApexBio Technology B2189 YM201636 5mg $96 2021-12-16 Buy
ApexBio Technology B2189 YM201636 10mM(in 1mL DMSO) $100 2021-12-16 Buy
ApexBio Technology B2189 YM201636 10mg $170 2021-12-16 Buy
ApexBio Technology B2189 YM201636 50mg $645 2021-12-16 Buy
ApexBio Technology B2189 YM201636 100mg $1100 2021-12-16 Buy
Biorbyt Ltd orb181182 YM201636 >98% 100mg $578 2021-12-16 Buy
Biorbyt Ltd orb181182 YM201636 >98% 250mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb181182 YM201636 >98% 1000mg $2691.1 2021-12-16 Buy
Biosynth Carbosynth FA137438 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide 1mg $50 2021-12-16 Buy
Biosynth Carbosynth FA137438 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide 2mg $90 2021-12-16 Buy
Biosynth Carbosynth FA137438 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide 5mg $200 2021-12-16 Buy
Biosynth Carbosynth FA137438 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine?carboxamide 10mg $350 2021-12-16 Buy

Properties

Melting point :>226°C (dec.)
Density :1.446
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Very Slightly)
form :Solid
color :Pale Beige to Light Beige
CAS DataBase Reference :371942-69-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PIKfyve is a phosphoinositide kinase (PIK) that contains a FYVE-type zinc finger domain, which binds phosphatidylinositol 3-phosphate (PI3P). PIKfyve phosphorylates PI3P to produce PI-(3,5)-P2, which is involved in cellular processes including membrane trafficking and cytoskeletal reorganization. YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA. YM-201636 also blocks retroviral exit by budding from cells, apparently by interfering with the endosomal sorting complex required for transport (ESCRT) machinery. In adipocytes, YM-201636 also inhibits basal and insulin-activated 2-deoxyglucose uptake (IC50 = 54 nM).

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