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ChemicalBook >> CAS DataBase List >> BTP2

BTP2

BTP2 price.
  • $34 - $1442
  • Product name: BTP2
  • CAS: 223499-30-7
  • MF: C15H9F6N5OS
  • MW: 421.32
  • EINECS:
  • MDL Number:MFCD00220976
  • Synonyms:BTP2;N-[4-[3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]PHENYL]-4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE;4-methyl-4μ-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide;YM-58483;CRAC Channel Inhibitor, BTP2;YM-58483(BTP2);BTP 2, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide;YM-5883
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • ChemScene
  • Crysdot
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Package
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  • 1g
  • ManufacturerAK Scientific
  • Product number0291CA
  • Product descriptionN-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
  • Packaging100mg
  • Price$340
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number0291CA
  • Product descriptionN-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
  • Packaging250mg
  • Price$594
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number0291CA
  • Product descriptionN-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
  • Packaging1g
  • Price$1442
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA172938
  • Product descriptionYM-58483 98+%
  • Packaging2mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA172938
  • Product descriptionYM-58483 98+%
  • Packaging5mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA172938
  • Product descriptionYM-58483 98+%
  • Packaging10mg
  • Price$128
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA172938
  • Product descriptionYM-58483 98+%
  • Packaging25mg
  • Price$167
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA172938
  • Product descriptionYM-58483 98+%
  • Packaging50mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0003625
  • Product descriptionYM-58483 95.00%
  • Packaging1MG
  • Price$138.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0003625
  • Product descriptionYM-58483 95.00%
  • Packaging5MG
  • Price$720.38
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0003625
  • Product descriptionYM-58483 95.00%
  • Packaging25MG
  • Price$1097.54
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB7542
  • Product descriptionYM58483
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7542
  • Product descriptionYM58483
  • Packaging50mg
  • Price$610
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS463109
  • Product descriptionYM-58483 ≥98%
  • Packaging5mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13246
  • Product descriptionYM-58483 ≥98%
  • Packaging1mg
  • Price$34
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13246
  • Product descriptionYM-58483 ≥98%
  • Packaging5mg
  • Price$150
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0291CA N-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide 100mg $340 2021-12-16 Buy
AK Scientific 0291CA N-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide 250mg $594 2021-12-16 Buy
AK Scientific 0291CA N-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide 1g $1442 2021-12-16 Buy
Ambeed A172938 YM-58483 98+% 2mg $55 2021-12-16 Buy
Ambeed A172938 YM-58483 98+% 5mg $98 2021-12-16 Buy
Ambeed A172938 YM-58483 98+% 10mg $128 2021-12-16 Buy
Ambeed A172938 YM-58483 98+% 25mg $167 2021-12-16 Buy
Ambeed A172938 YM-58483 98+% 50mg $218 2021-12-16 Buy
American Custom Chemicals Corporation INB0003625 YM-58483 95.00% 1MG $138.6 2021-12-16 Buy
American Custom Chemicals Corporation INB0003625 YM-58483 95.00% 5MG $720.38 2021-12-16 Buy
American Custom Chemicals Corporation INB0003625 YM-58483 95.00% 25MG $1097.54 2021-12-16 Buy
ApexBio Technology B7542 YM58483 10mg $175 2021-12-16 Buy
ApexBio Technology B7542 YM58483 50mg $610 2021-12-16 Buy
Arctom AS463109 YM-58483 ≥98% 5mg $97 2021-12-16 Buy
Cayman Chemical 13246 YM-58483 ≥98% 1mg $34 2024-03-01 Buy
Cayman Chemical 13246 YM-58483 ≥98% 5mg $150 2024-03-01 Buy

Properties

Melting point :165-167 °C
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :10.53±0.70(Predicted)
form :Solid
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Calcium release-activated calcium (CRAC) channels mediate sustained calcium influx in electrically non-excitable cells. CRAC channels are activated by the release of calcium from intracellular stores, as induced by inositol trisphosphate. CRAC channel activation is essential for the activation of leukocytes and the production of cytokines and inflammatory mediators. YM-58483 is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM). YM-58483 also inhibits lung interleukin-4 and cysteinyl leukotriene generation as well as airway eosinophil infiltration in animal models of asthma.

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