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ChemicalBook >> CAS DataBase List >> Binimetinib

Binimetinib

Binimetinib price.
  • $50.2 - $9990
  • Product name: Binimetinib
  • CAS: 606143-89-9
  • MF: C17H15BrF2N4O3
  • MW: 441.23
  • EINECS:
  • MDL Number:MFCD22124525
  • Synonyms:5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;MEK162 (ARRY-438162);MEK162 (ARRY-162, ARRY-438162);BiniMetinib (MEK162, ARRY-162, ARRY-438162);1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-;5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Binimetinib (MEK162, ARRY-162, ARRY-438162);ARRY-438162 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;Binimetinib
30 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
Package
  • 5MG
  • 10mg
  • 20mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1000mg
  • 1G
  • 5g
  • ManufacturerAK Scientific
  • Product numberY1468
  • Product descriptionMEK162
  • Packaging10mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001469
  • Product descriptionMEK-162 95.00%
  • Packaging5MG
  • Price$168.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001469
  • Product descriptionMEK-162 95.00%
  • Packaging1G
  • Price$1659
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1947
  • Product descriptionMEK162(ARRY-162,ARRY-438162)
  • Packaging10mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1947
  • Product descriptionMEK162(ARRY-162,ARRY-438162)
  • Packaging50mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1947
  • Product descriptionMEK162(ARRY-162,ARRY-438162)
  • Packaging100mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60181
  • Product descriptionBinimetinib(MEK162) ≥98%
  • Packaging20mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180927
  • Product descriptionMEK162(Binimetinib) >98%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180927
  • Product descriptionMEK162(Binimetinib) >98%
  • Packaging250mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180927
  • Product descriptionMEK162(Binimetinib) >98%
  • Packaging1000mg
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM65077
  • Product descriptionMEK162
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM65077
  • Product descriptionMEK162
  • Packaging50mg
  • Price$298
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16996
  • Product descriptionBinimetinib ≥98%
  • Packaging5mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16996
  • Product descriptionBinimetinib ≥98%
  • Packaging10mg
  • Price$107
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16996
  • Product descriptionBinimetinib ≥98%
  • Packaging50mg
  • Price$437
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16996
  • Product descriptionBinimetinib ≥98%
  • Packaging100mg
  • Price$765
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y1468 MEK162 10mg $138 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001469 MEK-162 95.00% 5MG $168.3 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001469 MEK-162 95.00% 1G $1659 2021-12-16 Buy
ApexBio Technology A1947 MEK162(ARRY-162,ARRY-438162) 10mg $65 2021-12-16 Buy
ApexBio Technology A1947 MEK162(ARRY-162,ARRY-438162) 50mg $150 2021-12-16 Buy
ApexBio Technology A1947 MEK162(ARRY-162,ARRY-438162) 100mg $240 2021-12-16 Buy
Arctom CFN60181 Binimetinib(MEK162) ≥98% 20mg $168 2021-12-16 Buy
Biorbyt Ltd orb180927 MEK162(Binimetinib) >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb180927 MEK162(Binimetinib) >98% 250mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb180927 MEK162(Binimetinib) >98% 1000mg $1949.9 2021-12-16 Buy
Biosynth Carbosynth FM65077 MEK162 10mg $85 2021-12-16 Buy
Biosynth Carbosynth FM65077 MEK162 50mg $298 2021-12-16 Buy
Cayman Chemical 16996 Binimetinib ≥98% 5mg $57 2024-03-01 Buy
Cayman Chemical 16996 Binimetinib ≥98% 10mg $107 2024-03-01 Buy
Cayman Chemical 16996 Binimetinib ≥98% 50mg $437 2024-03-01 Buy
Cayman Chemical 16996 Binimetinib ≥98% 100mg $765 2024-03-01 Buy

Properties

Melting point :>203oC (dec.)
Density :1.67
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :14.20±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Precautionary statements:
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM). It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM). This compound is efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-Raf mutations, and has been characterized in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer.

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