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ChemicalBook >> CAS DataBase List >> Alpelisib (BYL719)

Alpelisib (BYL719)

Alpelisib (BYL719) price.
  • $25 - $2691.1
  • Product name: Alpelisib (BYL719)
  • CAS: 1217486-61-7
  • MF: C19H22F3N5O2S
  • MW: 441.47
  • EINECS:
  • MDL Number:MFCD22417085
  • Synonyms:(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide;BYL-719 /BYL719;BLV-719;(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide;1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-;Alpelisib (BYL719);(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719;BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
40 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1unit
  • 10mM(in 1mL DMSO)
  • 005
  • 1mg
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 1000mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1230-M001
  • Product descriptionAlpelisib ≥95%
  • Packaging1mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1230
  • Product descriptionAlpelisib
  • Packaging1mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA130937
  • Product description(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+%
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA130937
  • Product description(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+%
  • Packaging5mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA130937
  • Product description(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+%
  • Packaging10mg
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA130937
  • Product description(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+%
  • Packaging50mg
  • Price$92
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA130937
  • Product description(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+%
  • Packaging100mg
  • Price$183
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA130937
  • Product description(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+%
  • Packaging250mg
  • Price$407
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA130937
  • Product description(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+%
  • Packaging1g
  • Price$1015
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8346
  • Product descriptionBYL-719
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8346
  • Product descriptionBYL-719
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8346
  • Product descriptionBYL-719
  • Packaging10mM(in 1mL DMSO)
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8346
  • Product descriptionBYL-719
  • Packaging20mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8346
  • Product descriptionBYL-719
  • Packaging100mg
  • Price$704
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60095
  • Product descriptionAlpelisib(BYL719)
  • Packaging20mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2925
  • Product descriptionAlpelisib-NVP-BYL719|BYL-719 98%
  • Packaging10mg
  • Price$99
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1230-M001 Alpelisib ≥95% 1mg $86 2021-12-16 Buy
AK Scientific SYN1230 Alpelisib 1mg $100 2021-12-16 Buy
Ambeed A130937 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+% 1mg $25 2021-12-16 Buy
Ambeed A130937 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+% 5mg $42 2021-12-16 Buy
Ambeed A130937 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+% 10mg $54 2021-12-16 Buy
Ambeed A130937 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+% 50mg $92 2021-12-16 Buy
Ambeed A130937 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+% 100mg $183 2021-12-16 Buy
Ambeed A130937 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+% 250mg $407 2021-12-16 Buy
Ambeed A130937 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide 99+% 1g $1015 2021-12-16 Buy
ApexBio Technology A8346 BYL-719 1unit $28 2021-12-16 Buy
ApexBio Technology A8346 BYL-719 5mg $90 2021-12-16 Buy
ApexBio Technology A8346 BYL-719 10mM(in 1mL DMSO) $100 2021-12-16 Buy
ApexBio Technology A8346 BYL-719 20mg $200 2021-12-16 Buy
ApexBio Technology A8346 BYL-719 100mg $704 2021-12-16 Buy
Arctom CFN60095 Alpelisib(BYL719) 20mg $218 2021-12-16 Buy
Axon Medchem Axon2925 Alpelisib-NVP-BYL719|BYL-719 98% 10mg $99 2021-12-16 Buy

Properties

Density :1.391
storage temp. :Store at -20°C
solubility :≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :White solid.
pka :6.29±0.70(Predicted)
color :Off-white to light yellow
InChIKey :STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES :N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P314 Get medical advice/attention if you feel unwell.
P501 Dispose of contents/container to..…

Description

BYL719 is a selective inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). It is less effective against PI3K isoforms β, γ, and δ (IC50s = 1,156, 250, and 290 nM) as well as a range of related kinases. BYL719 is effective in vivo, as it dose-dependently inhibits the growth of PI3Kα-dependent xenograft tumors in mice. Effectiveness against wild type and mutant PI3Kα-dependent tumors may be augmented by combination therapy with inhibitors of other kinases. Combination therapy may be necessary, as loss of downstream pathway components can confer clinical resistance to BYL719.