BI 2536
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- $37 - $2839
- Product name: BI 2536
- CAS: 755038-02-9
- MF: C28H39N7O3
- MW: 521.65
- EINECS:1308068-626-2
- MDL Number:MFCD10565924
- Synonyms:BI-2536, BoehringerPLK-1 inhibitor;4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide;BI 2536;Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-;Boehringer PLK-1 inhibitor;BI-2536(R-);BI2536/BI-2536;(R)-4-((8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)aMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide
42 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- BLDpharm
- BroadPharm
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 5mg
- 10mg
- 20MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1019-M005
- Product description(R)-BI-2536 ≥95%
- Packaging5mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203461
- Product descriptionBI-2536 98+%
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203461
- Product descriptionBI-2536 98+%
- Packaging10mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203461
- Product descriptionBI-2536 98+%
- Packaging50mg
- Price$382
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203461
- Product descriptionBI-2536 98+%
- Packaging100mg
- Price$497
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA203461
- Product descriptionBI-2536 98+%
- Packaging1g
- Price$840
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000643
- Product descriptionBI-2536 95.00%
- Packaging20MG
- Price$1870
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3965
- Product descriptionBI2536
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022120
- Product descriptionBI-2536 ≥98%
- Packaging5mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022120
- Product descriptionBI-2536 ≥98%
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60044
- Product descriptionBI2536 ≥98%
- Packaging10mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022120
- Product descriptionBI-2536 ≥98%
- Packaging50mg
- Price$378
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022120
- Product descriptionBI-2536 ≥98%
- Packaging100mg
- Price$492
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022120
- Product descriptionBI-2536 ≥98%
- Packaging1g
- Price$832
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2626
- Product descriptionBI 2536
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2626
- Product descriptionBI 2536
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1019-M005 | (R)-BI-2536 ≥95% | 5mg | $124 | 2021-12-16 | Buy |
| Ambeed | A203461 | BI-2536 98+% | 5mg | $90 | 2021-12-16 | Buy |
| Ambeed | A203461 | BI-2536 98+% | 10mg | $162 | 2021-12-16 | Buy |
| Ambeed | A203461 | BI-2536 98+% | 50mg | $382 | 2021-12-16 | Buy |
| Ambeed | A203461 | BI-2536 98+% | 100mg | $497 | 2021-12-16 | Buy |
| Ambeed | A203461 | BI-2536 98+% | 1g | $840 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000643 | BI-2536 95.00% | 20MG | $1870 | 2021-12-16 | Buy |
| ApexBio Technology | A3965 | BI2536 | 10mg | $150 | 2021-12-16 | Buy |
| Arctom | AS022120 | BI-2536 ≥98% | 5mg | $89 | 2021-12-16 | Buy |
| Arctom | AS022120 | BI-2536 ≥98% | 10mg | $160 | 2021-12-16 | Buy |
| Arctom | CFN60044 | BI2536 ≥98% | 10mg | $288 | 2021-12-16 | Buy |
| Arctom | AS022120 | BI-2536 ≥98% | 50mg | $378 | 2021-12-16 | Buy |
| Arctom | AS022120 | BI-2536 ≥98% | 100mg | $492 | 2021-12-16 | Buy |
| Arctom | AS022120 | BI-2536 ≥98% | 1g | $832 | 2021-12-16 | Buy |
| AvaChem | 2626 | BI 2536 | 5mg | $75 | 2021-12-16 | Buy |
| AvaChem | 2626 | BI 2536 | 10mg | $125 | 2021-12-16 | Buy |
Properties
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form :Yellow powder.
pka :14.09±0.20(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :XQVVPGYIWAGRNI-JOCHJYFZSA-N
SMILES :C(NC1CCN(C)CC1)(=O)C1=CC=C(NC2=NC=C3C(=N2)N(C2CCCC2)[C@H](CC)C(=O)N3C)C(OC)=C1
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form :Yellow powder.
pka :14.09±0.20(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :XQVVPGYIWAGRNI-JOCHJYFZSA-N
SMILES :C(NC1CCN(C)CC1)(=O)C1=CC=C(NC2=NC=C3C(=N2)N(C2CCCC2)[C@H](CC)C(=O)N3C)C(OC)=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. BI 2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM). It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI 2536 induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice. It shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells. BI 2536 is also an inhibitor of BRD4 (IC50 = 25 nM), suppressing BRD4-dependent c-Myc expression in MM.1S multiple myeloma cells.More related product prices
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