成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion

Phenylbutazone Struktur
50-33-9
CAS-Nr.
50-33-9
Bezeichnung:
4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion
Englisch Name:
Phenylbutazone
Synonyma:
PBZ;Benzone;4-Phenylbutazone;Bute;Butone;Azolid;Butalan;Butadione;Baotaisong;Butazolidin
CBNumber:
CB0370134
Summenformel:
C19H20N2O2
Molgewicht:
308.37
MOL-Datei:
50-33-9.mol

4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Eigenschaften

Schmelzpunkt:
106-108 °C (lit.)
Siedepunkt:
448.76°C (rough estimate)
Dichte
1.1591 (rough estimate)
Brechungsindex
1.6140 (estimate)
storage temp. 
2-8°C
L?slichkeit
Practically insoluble in water, sparingly soluble in alcohol. It dissolves in alkaline solutions.
Aggregatzustand
Powder
pka
4.5(at 25℃)
Farbe
White to almost white
Biologische Quelle
synthetic (organic)
Wasserl?slichkeit
<0.1 g/100 mL at 23.5 ºC
Merck 
14,7277
BRN 
290080
Stabilit?t:
Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey
VYMDGNCVAMGZFE-UHFFFAOYSA-N
LogP
3.160
CAS Datenbank
50-33-9(CAS DataBase Reference)
NIST chemische Informationen
Phenylbutazone(50-33-9)
IARC
3 (Vol. 13, Sup 7) 1987
EPA chemische Informationen
Phenylbutazone (50-33-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,T,F
R-S?tze: 36/37/38-20/21/22-42/43-45-36-11
S-S?tze: 36/37/39-26-45-22-53-36/37-16
RIDADR  3249
WGK Germany  3
RTECS-Nr. UQ8225000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29331990
Giftige Stoffe Daten 50-33-9(Hazardous Substances Data)
Toxizit?t LD50 oral in rabbit: 781mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R45:Kann Krebs erzeugen.

S-S?tze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.

Beschreibung

Phenylbutazone, one of the earliest NSAIDs introduced, is now indicated for the symptomatic relief of rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, gout, and acute superficial thrombophlebitis. The gastrointestinal and bone marrow toxicity observed in its early use have been greatly reduced by lower dosage (300 mg/d). Nevertheless, it is used primarily where other drugs have failed and then only for short-term therapy. The drug has a long serum half-life of about 100 h. It is a moderately active cyclooxygenase inhibitor and it suppresses both spontaneous and chemotactic motility of neutrophils. In addition to the serious gastrointestinal and hematological adverse effects, sodium and water retention, rash, vertigo, and dermatitis are observed.

Chemische Eigenschaften

Off-Whtie Solid

Verwenden

Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively.

Weltgesundheitsorganisation (WHO)

Phenylbutazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1949 for the treatment of rheumatic disorders. Its use was subsequently associated with serious and sometimes fatal adverse reactions, notably cases of aplastic anaemia and agranulocytosis. Many national drug regulatory authorities consider that more recently introduced drugs offer a safer alternative for most, if not all, patients requiring anti-inflammatory agents. Phenylbutazone has thus been either withdrawn at the national level or retained with rigorously restricted indications for patients unresponsive to other therapy. These restrictions also apply, in general, to combination products containing phenylbutazone.

Allgemeine Beschreibung

Odorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2.

Air & Water Reaktionen

Phenylbutazone is relatively stable at ambient temperatures. Aqueous decomposition of Phenylbutazone occurs by hydrolysis and oxidation. Insoluble in water.

Reaktivit?t anzeigen

Phenylbutazone is incompatible with strong oxidizers, strong acids and strong bases. .

Brandgefahr

Flash point data for Phenylbutazone are not available; however, Phenylbutazone is probably combustible.

Sicherheitsprofil

Suspected human carcinogen producing leukemia. A human poison by parenteral route. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion and possibly other routes: fever, blood pressure increase, other unspecified vascular effects, damage to kidney tubules and glomeruli, decreased urine volume, blood in the urine, reduction in the number of whte blood cells, and agranulocytosis. Experimental teratogenic and reproductive effects. Human mutation data reported. An eye irritant. An antiinflammatory agent. When heated to decomposition it emits toxic fumes of NOx

l?uterung methode

Crystallise the dione from EtOH. Its pK2 3 is 4.52 (in H2O), 4.89 (in 50% aqueous EtOH) and 5.25 (80% 2-methoxyethanol). It complexes with Hg2+, Cd2+ and Zn2+. It has UV with max at 239.5nm in MeOH+50% aqueous HClO4 and 264nm in aqueous 0.1N NaOH. [Beilstein 24 III/IV 1123.]

4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 504)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8806 58
Hebei Mujin Biotechnology Co.,Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12830 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838
evan@tyvovo.com China 148 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hebei Ganmiao New material Technology Co., LTD
+86-17332992504 +86-17332992504
sales8@hbganmiao.com China 300 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 484 58
Shanghai Bojing Chemical Co.,Ltd.
+86-86-02137122233 +8613795318958
bj1@bj-chem.com China 299 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29879 58

50-33-9(4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion)Verwandte Suche:


  • Ecobutazone
  • Elmedal
  • Equi bute
  • equibute
  • equipalazone
  • Eributazone
  • 'Esteve'
  • exrheudonn
  • Febuzina
  • Fenartil
  • Fenibutal
  • Fenibutasan
  • Fenibutazona
  • Fenibutol
  • Fenilbutina
  • Fenilbutine
  • Fenilidina
  • Fenotone
  • Fenylbutazon
  • Flexazone
  • G 13,871
  • g13,871
  • PHENYLBUTAZONE
  • 1,2-Diphenyl-2,3-dioxo-4-N-butylpyrazoline
  • 1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine
  • 1,2-Diphenyl-4-butyl-3,5-dioxopyrazolidine
  • 1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione
  • Betazed
  • bizolin
  • Bizolin 200
  • bizolin200
  • Bunetzone
  • Busone
  • Buta phen
  • Butacompren
  • Butacote
  • Butadion
  • Butadiona
  • Butagesic
  • Butalgina
  • Butalidon
  • Butaluy
  • Butapirazol
  • Butapirazole
  • Butapyrazole
  • Butarecbon
  • Butartril
  • Butartrina
  • Butazina
  • Butazolidine
  • Butazona
  • Butazone
  • Butidiona
  • Butiwas-Simple
  • Butoz
  • Butylpyrin
  • Buvetzone
  • Buzon
Copyright 2019 ? ChemicalBook. All rights reserved