90779-69-4
90779-69-4 結(jié)構(gòu)式
基本信息
阿托西班
1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin
oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l
rwj22164
1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin
[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2
(2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin
Atosiban
Human Atosiban
1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile, 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
醋酸阿托西班是由9個(gè)氨基酸組成的二硫鍵型的環(huán)狀多肽，是1，2，4和8位修飾的縮宮素分子，肽的N端為3-巰基丙酸(巰基與[Cys]6的巰基形成二硫鍵)，C端為酰胺的形式，N端第二氨基酸是乙基化修飾的[D-Tyr(Et)]2，醋酸阿托西班在藥品中以醋酸鹽的形式存在，通用名為醋酸阿托西班。
Tractocile?
Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca 2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua.
The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes.
Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice.