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69304-47-8

中文名稱 溴夫定
英文名稱 Brivudine
CAS 69304-47-8
分子式 C11H13BrN2O5
分子量 333.14
MOL 文件 69304-47-8.mol
更新日期 2024/12/23 11:22:49
69304-47-8 結(jié)構(gòu)式 69304-47-8 結(jié)構(gòu)式

基本信息

中文別名
溴呋啶
溴夫啶
溴夫定
布里夫定
溴比夫定
布瑞夫定
溴乙烯尿苷
溴夫定/溴夫啶
溴夫定(標(biāo)準(zhǔn)品)
(E)-5-(2-溴乙烯基)-2'-脫氧核苷
英文別名
BVDU
BVDR
BrVDU
Helpin
Brivudin
SC-38394
BRIVUDINE
Brivudine BVdU
Brivudine USP/EP/BP
Bromovinyldeoxyuridine

物理化學(xué)性質(zhì)

熔點(diǎn)165°C
密度1.7800 (rough estimate)
折射率1.6520 (estimate)
儲(chǔ)存條件2-8°C
溶解度可溶于DMSO(少許)、甲醇(少許)
酸度系數(shù)(pKa)8.37±0.10(Predicted)
形態(tài)固體
顏色米白色
水溶解性Soluble in water and methanol.
Merck14,1378
InChIKeyODZBBRURCPAEIQ-CXYVBZRVSA-N

安全數(shù)據(jù)

安全說(shuō)明24/25
WGK Germany3
RTECS號(hào)YU7355000
海關(guān)編碼29349990
溴夫定價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/11XW6930447803溴夫定69304-47-81G863元
2024/11/11XW6930447801溴夫定69304-47-850MG93元
2024/11/08H27853(E)-5-(2-溴乙烯基)-2'-脫氧核苷, 98%
(E)-5-(2-Bromovinyl)-2'-deoxyuridine, 98%
69304-47-850mg793元

常見(jiàn)問(wèn)題列表

生物活性
Brivudine是具有抗病毒活性的胸苷類似物,用于早期急性帶狀皰疹的研究。
體外研究

Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.

體內(nèi)研究

At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia.

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