| Identification | Back Directory | [Name]
Brivudine | [CAS]
69304-47-8 | [Synonyms]
BVDU
BVDR
BrVDU
Helpin
SC-38394
Brivudin
BRIVUDINE
Brivudine
BVdU
Brivudine USP/EP/BP
Bromovinyldeoxyuridine
BROMOVINYLDEOXYURIDINE; BVDU
5-(2-Bromovinyl)-deoxy-uridine
Brivudine(BroMovinyldeoxyuridine)
(E)-(5)-BROMOVINYL-2-DEOXYURIDINE
5-(E)-(2-Bromovinyl)-2-deoxyuridine
(E)-5-(2-BROMOVINYL)-2'-DEOXY-URIDINE
(E)-5-(2-Bromovinyl)-2'-deoxyuridine >
Uridine,5-[(1E)-2-broMoethenyl]-2'-deoxy-
(E)-5-(2-Bromovinyl)-2'-deoxyuridine
5-[(E)-2-Bromoethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5-((E)-2-bromovinyl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
BrivudineQ: What is
Brivudine Q: What is the CAS Number of
Brivudine Q: What is the storage condition of
Brivudine Q: What are the applications of
Brivudine | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C11H13BrN2O5 | [MDL Number]
MFCD00058585 | [MOL File]
69304-47-8.mol | [Molecular Weight]
333.14 |
| Chemical Properties | Back Directory | [Melting point ]
165°C | [density ]
1.7800 (rough estimate) | [refractive index ]
1.6520 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.37±0.10(Predicted) | [color ]
Off-White | [Water Solubility ]
Soluble in water and methanol. | [Merck ]
14,1378 | [InChIKey]
ODZBBRURCPAEIQ-CXYVBZRVSA-N |
| Hazard Information | Back Directory | [Description]
(E)-5-(2-Bromovinyl)-2'-deoxyuridine is an thymidine analogue and acts as an anti-viral by inhibiting DNA plymerase. | [Chemical Properties]
White solid | [Uses]
It is used as pharmaceutical intermediate. | [Enzyme inhibitor]
This halogenated nucleoside (FW = 333.14 g/mol), also known as brivudin
and 5-[ (E) -2-bromoethenyl]-2’-deoxyuridine, is an antiherpetic agent that
inhibits viral DNA polymerase. BvdU is a highly potent and selective
inhibitor of herpes simplex virus type 1 and varicella-zoster virus infections.
Target (s) : DNA polymerase, viral, via the 5’-triphosphate ; HSV-1
replication ; 5’ nucleotidases; dTMP kinase, or thymidylate kinase
; deoxynucleoside kinase, also alternative substrate; thymidine
kinase. |
|
|