652-67-5
基本信息
異山梨醇
1,4:3,6-二無水-D-山梨糖醇
異山梨酯
1,4:3,6-DIANHYDRO-D-SORBITOL
1,4:3,6-DIANHYDROGLUCITOL
1,4:3,6-DIANHYDROSORBITOL
(3S,3AR,6R,6AR)-HEXAHYDRO-FURO[3,2-B]FURAN-3,6-DIOL
DIANHYDRO-D-GLUCITOL
DIANHYDRO-D-SORBITOL
D-ISOSORBIDE
ISOSORBIDE
1,4:3,6-dianhydro-d-glucito
4:3,6-dianhydro-d-glucito
at101
d-1,4:3,6-dianhydroglucitol
devicoran
hydronol
isobide
Isosorbide,typically98%
Isosorbid
D-Glucitol, 1,4:3,6-dianhydro-
D-Glucitol, 1,4:3,6-dianhydro- (9CI)
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
異山梨醇是山梨醇的脫水衍生物,為一口服滲透性脫水利尿藥,作用機(jī)制類似于靜注甘露醇和山梨醇。通過提高血漿滲透壓,導(dǎo)致組織內(nèi)(包括眼、腦、腦脊液等)水分進(jìn)入血管內(nèi),從而減輕組織水腫,降低眼內(nèi)壓、顱內(nèi)壓和腦脊液容量及其壓力。異山梨醇注意用于治療腦水腫及青光眼。
異山梨醇作為山梨醇的二次脫水衍生物,是一種新型生物基材料、用途廣泛的化工中間體。異山梨醇藥用價值顯著,廣泛應(yīng)用于醫(yī)藥、食品、化工、飼料添加劑等行業(yè)。異山梨醇在聚合物改性及聚合物降解方面的應(yīng)用已經(jīng)開始,進(jìn)一步擴(kuò)展了異山梨醇的應(yīng)用領(lǐng)域。
Isosorbide通過增加尿液中滲透活性溶質(zhì)的量增加尿量。滲透性利尿藥也增加血漿的滲透壓摩爾濃度。Isosorbide用于預(yù)防或治療胸痛(心絞痛)。它的作用原理是,通過放松血管和心臟,使心臟的供血和供氧量增加。
Isosorbide (5 mg/kg; a single p.o.) significantly increases the urine volume of rats within 2 hours which lasts through the 8 hour experimental period.
Isosorbide (5 mg/kg; a single p.o. 30 min prior to gallium injection) significantly reduces the urinary concentrations of both gallium and calcium in rats.
Isosorbide (5 mg/kg; p.o. 30 min prior to gallium injection for 6 d) results in the formation of fewer renal precipitates and histopathologic changes than in the nondiuresed animals.
知名試劑公司產(chǎn)品信息
Isosorbide, 98%(652-67-5)
D-Isosorbide, 98%(652-67-5)
Isosorbide,>98.0%(GC)(652-67-5)