成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>1438391-30-0

1438391-30-0

中文名稱 3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑鹽酸鹽
英文名稱 CC401 HCl
CAS 1438391-30-0
分子式 C22H25ClN6O
分子量 424.927
MOL 文件 1438391-30-0.mol
更新日期 2024/06/12 17:31:29
1438391-30-0 結(jié)構(gòu)式 1438391-30-0 結(jié)構(gòu)式

基本信息

中文別名
CC-401鹽酸鹽
化合物CC-401 HYDROCHLORIDE
JNK抑制劑(CC-401 HYDROCHLORIDE)
3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑鹽酸鹽
英文別名
CC-401 (hydrochloride)
CC-401 dihydrochloride >=95% (HPLC)
CC 401 HYDROCHLORIDE
CC401 HYDROCHLORIDE
CC401 HCL
3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride (1:1)
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 100 mg/mL (235.33 mM; Need ultrasonic)
形態(tài)白色粉末
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
海關(guān)編碼2933399990
3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑鹽酸鹽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-130223-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑鹽酸鹽
CC-401 hydrochloride
1438391-30-05mg900元
2024/11/08HY-130223-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑鹽酸鹽
CC-401 hydrochloride
1438391-30-010mM * 1mLin DMSO990元
2024/11/08HY-130223-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑鹽酸鹽
CC-401 hydrochloride
1438391-30-010mg1400元

常見問題列表

生物活性
CC-401是有效的JNK抑制劑,其對(duì)JNK的選擇性是對(duì)其他相關(guān)性激酶的選擇性的至少40倍。
靶點(diǎn)

JNK

25-50 nM (Ki)

體外研究

CC-401 has at least 40-fold selectivity for JNK compared with other related kinases, including p38, extracellular signal-regulated kinase (ERK), inhibitor of κB kinase (IKK2), protein kinase C, Lck, zeta-associated protein of 70 kDa (ZAP70). In cell-based assays, 1 to 5 μM CC-401 provides specific JNK inhibition. CC-401, a small molecule that is a specific inhibitor of all three JNK isoforms. CC-401 competitively binds the ATP binding site in JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of the transcription factor c-Jun. The specificity of this inhibitor is tested in vitro using osmotic stress of the HK-2 human tubular epithelial cell line. CC-401 inhibits sorbitol-induced phosphorylation of c-Jun in a dosage-dependent manner. However, CC-401 does not prevent sorbitol-induced phosphorylation of JNK, p38, or ERK.

體內(nèi)研究

The staining of p-JNK is moderately induced in bevazicumab and Oxaliplatin treatments as compared to control, and in the CC-401-treated samples p-cJun content is significantly lower, consistent with effective JNK inhibition. DNA damage is modestly elevated in combined treatments with CC-401. CC-401 treatment from days 7 to 24 slows the progression of proteinuria, which is significantly reduced compared to the no-treatment and vehicle groups at days 14 and 21. However, there is still an increase in the degree of proteinuria at day 21 in CC-401-treated rats compared to proteinuria at day 5. The vehicle and no-treatment groups developed renal impairment at day 24 as shown by an increase in serum creatinine. This is prevented by CC-401 treatment.

"1438391-30-0" 相關(guān)產(chǎn)品信息
75-36-5 955028-98-5 606143-89-9 944396-07-0 475108-18-0 404828-08-6 6493-06-7 849217-68-1 1110813-31-4 612847-09-3 918504-65-1