1358-76-5
1358-76-5 結(jié)構(gòu)式
基本信息
闊胺
鉤吻堿子
鉤吻素子
鉤吻素子(闊胺)
鉤吻素子對(duì)照品,
鉤吻素子,鉤吻堿子
鉤吻素子(標(biāo)準(zhǔn)品)
KOUMINE 鉤吻素子
(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan
7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-
6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
藥理藥效:對(duì)精神神經(jīng)、呼吸及心血管系統(tǒng)有一定的刺激興奮作用，具有用于治療神經(jīng)病理性疼痛的潛在價(jià)值。
常見問題列表
Koumine (0.5, 1 and 2 mg/mL) dose- and time-dependently inhibits the proliferation of MCF-7 cells, with an IC
50
of 124 μg/mL at 72 h. Koumine induces apoptosis, causes cell cycle arrest at G2/M phase.
Koumine (0.5, 1 and 2 mg/mL) up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in a dose-dependent manner in MCF-7 Cells.
Koumine (25, 50, 100, and 200?μM) decreases the protein and mRNA levels of microglia M1 polarization factors in LPS-induced BV2 cells.
Koumine is less toxic, with the median lethal dose (LD
50
) of 300.0 mg/kg on Wistar rats. Koumine (0.6, 3, or 15 mg/kg/per, p.o.) exhibits antirheumatic properties in rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA).
Koumine inhibits the increase in cytokines in joint tissue and TNF-α level in serum at 15 mg/kg, and suppresses the increase in the serum level of IL-1β at 3 and 15 mg/kg.
Koumine (0.28, 7 mg/kg, s.c.) significantly reduces neuropathic pain after nerve injury. Koumine suppresses the increased Iba-1 protein level.