105956-97-6
105956-97-6 結(jié)構(gòu)式
基本信息
克林沙星
1-環(huán)丙基-6-氟-7-(3-氨基吡咯烷-1- 基)-8-氯-1,4-二氫-4-氧-喹啉-3-羧酸
CLINAFLOXACIN
7-(3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-
6-Fluoro-8-chloro-1-cyclopropyl-7-(3-aminopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CI-960
PD-127391
物理化學(xué)性質(zhì)
常見問題列表
| Target | Value |
| Topoisomerase IV | |
| DNA gyrase |
Clinafloxacin是一個喹諾酮羧酸類的廣譜抗生素，目前用于嚴(yán)重感染的靜脈注射和口服治療。 Clinafloxacin是一個新型的氟喹諾酮。在體外具有抗革蘭氏陽性，革蘭氏陰性，和厭氧病原體的廣譜活性。Clinafloxacin對肺炎鏈球菌7785 (MIC，0.125 微克/毫升)具有較高活性，并且非gyrA 或parC喹諾酮耐藥突變單獨(dú)對該活性具有更好的作用。與ofloxacin，levofloxacin，sparfloxacin，grepafloxacin，以及trovafloxacin相比，Clinafloxacin被認(rèn)為是最有效的抗S. pneumoniae氟喹諾酮，目前被認(rèn)為是一個抗肺炎鏈球菌藥。
Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.