| Identification | More | [Name]
N-Methylpiperidine | [CAS]
626-67-5 | [Synonyms]
1-METHYLPIPERIDINE
N-MEPIP
N-METHYLPIPERIDINE
NMPPR
1-methyl-piperidin
lk20
Piperidine,1-methyl-
1-Pipecoline
1-METHYLPIPERIDINE SOLUTION
1-METHYLPIPERIDINE SOLUTION, FOR PROT.SE Q. ANAL., 40 ML
1-METHYLPIPERIDINE 98+%
1-METHYLPIPERIDINE PROTEIN*SEQUENCING GR ADE
N-Methylpiperidine/1-Methylpiperidine/Picoline
1-Methylpiperidine,97%
N-Methylpiperidine,98%
1-METHYLPIPERDINE
N-METHYL PIPERIDINE 1-METHYL-PIPERIDINE | [EINECS(EC#)]
210-959-9 | [Molecular Formula]
C6H13N | [MDL Number]
MFCD00006491 | [Molecular Weight]
99.17 | [MOL File]
626-67-5.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS LIQUID | [Melting point ]
-50 °C
| [Boiling point ]
106-107 °C (lit.) | [density ]
0.817 g/mL at 20 °C(lit.)
| [vapor pressure ]
35.7hPa at 20℃ | [refractive index ]
n20/D 1.438
| [Fp ]
38 °F
| [storage temp. ]
−20°C
| [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
Liquid | [pka]
10.08(at 25℃) | [color ]
Clear colorless | [PH]
12 (100g/l, H2O, 20℃) | [explosive limit]
1.1-9.9%(V) | [Water Solubility ]
miscible | [BRN ]
1073 | [Dielectric constant]
2.5899999999999999 | [LogP]
1.15 at 25℃ | [CAS DataBase Reference]
626-67-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Piperidine, 1-methyl-(626-67-5) | [EPA Substance Registry System]
626-67-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,F,T | [Risk Statements ]
R11:Highly Flammable.
R34:Causes burns.
R20/22:Harmful by inhalation and if swallowed .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R67:Vapors may cause drowsiness and dizziness.
R22:Harmful if swallowed.
R10:Flammable. | [Safety Statements ]
S7:Keep container tightly closed .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S9:Keep container in a well-ventilated place .
S33:Take precautionary measures against static discharges . | [RIDADR ]
UN 3286 3/PG 2
| [WGK Germany ]
3
| [RTECS ]
TN1225000
| [F ]
3-10 | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29333999 | [Safety Profile]
Poison by
intraperitoneal and subcutaneous routes. A very dangerous fire hazard when exposed to
heat or flame. When heated to
decomposition it emits toxic fumes of NOx. | [Toxicity]
LD50 intraperitoneal in mouse: 400mg/kg |
| Hazard Information | Back Directory | [General Description]
A colorless liquid with the odor of pepper. Density 0.816 g/cm3 and flash point 38°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals. | [Reactivity Profile]
1-METHYLPIPERIDINE(626-67-5) neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. | [Air & Water Reactions]
Highly flammable. Soluble in water. | [Health Hazard]
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. | [Fire Hazard]
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. | [Description]
This simple piperidine derivative has been obtained from Girgensohnia diptera Bge. It is optically inactive and furnishes a crystalline picrate, m.p. 15 I-2°C and a picrolonate, m.p. 226°C. | [Chemical Properties]
CLEAR COLOURLESS LIQUID | [Uses]
Reactant for:
·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
·One-pot synthesis of Z-cinnamic acids
Reactant for synthesis of:
·Unsymmetrical ureas
·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts
·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling
·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases
| [Flammability and Explosibility]
Highlyflammable | [Toxics Screening Level]
The Initial Threshold Screening Level (ITSL) for n-methylpiperidine is 8 μg/m3 based on an annual averaging time. | [References]
Jurashevskii, Stepanov,J. Gen. Chem. USSR, 9,2203 (1939) |
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