| Identification | More | [Name]
1-Methyl-4-piperidone | [CAS]
1445-73-4 | [Synonyms]
1-METHYL-4-PIPERIDINONE
1-METHYL-4-PIPERIDONE
1-METHYLTETRAHYDROPYRIDIN-4(1H)-ONE
4-PIPERIDINONE, 1-METHYL-
AKOS BBS-00004237
N-METHYL-4-PIPERIDONE
N-METHYL-GAMMA-PIPERIDONE
N-METHYLPIPERIDONE
1-Methyl-4-oxopiperidine
1-Methyl-4-piperidione
1-Methyl-piperidin-4-one
1-Methylpiperidine-4-one
1-Methylpiperidone-(4)
4-Piperidone, 1-methyl-
4-Piperidone,1-methyl-
N-Methyl-4-piperidinone
N-Methyl-4-piperidon
1-Methylpiperid-4-one
N-METHYLPIPERIDIN-4-ONE
1-METHYL-4-PIPERIDONE 98% | [EINECS(EC#)]
215-895-5 | [Molecular Formula]
C6H11NO | [MDL Number]
MFCD00006191 | [Molecular Weight]
113.16 | [MOL File]
1445-73-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow to orange liquid | [Melting point ]
192-193 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
55-60 °C11 mm Hg(lit.)
| [density ]
0.973 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.460
| [Fp ]
140 °F
| [storage temp. ]
0-6°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
8.02±0.20(Predicted) | [color ]
Clear yellow to orange | [Specific Gravity]
0.92 | [PH]
12 (100g/l, H2O, 20℃) | [Water Solubility ]
MISCIBLE | [Sensitive ]
Air Sensitive | [BRN ]
106924 | [CAS DataBase Reference]
1445-73-4(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Piperidinone, 1-methyl-(1445-73-4) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 1224 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333999 |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
N-Methyl-3-carbomethoxy-4-piperidone hydrochloride-->4-Chloro-N-methylpiperidine-->2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE-->N-Methyl-4-piperidinol-->5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride-->5-BENZYL-2-METHYL-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE-->ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE-->5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE-->4-METHYLENEPIPERIDINE-->PYRIDINE, 4,4'-[1,1'-BIPHENYL]-4,4'-DIYLBIS--->5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE-->4-CHLORO-3-IODOPYRIDINE-->N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate-->1-(1-Methyl-4-piperidinyl)piperazine |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow to orange liquid | [Uses]
1-Methyl-4-piperidone, are widely used in artificial fibre industry. They are polymerizable and used as nylon precursors. They have excellent applications as solvents and as intermediates for organic synthesis. They are used in the aqueous carrier medium and amide penetrants in inks and water soluble paints. | [Application]
N-Methyl-4-piperidone can be used as a reactant to prepare:
Spiropiperidine rings by reacting with malononitrile and electrophiles or Michael acceptors.
(3E,5E)-1-Methyl-3,5-bis(phenylmethylene)-4-piperidinone by reacting with benzaldehyde via Michael addition, followed by intramolecular O-cyclization/elimination sequential reactions.
N,N′-Dimethylbispidinone by utilizing a double Mannich condensation method. | [Preparation]
[JACS (1948) vol 70 p 1820] for the synthesis of 1-methyl-4-piperidone:
To a one-liter flask containing 350 ml of 20 % hydrochloric acid was added 86 g. of 1-methyl-3-carbethoxy-4-piperidone hyrdrochloride. After refluxing for one hour, the ferric chloride reagent gave no coloration. The solution was evaporated to dryness on a steam-bath at 10 mm. pressure. The solid product, heated at 100 °C for 4 hours at 0.1 mm and further dried over solid KOH for 24 hours, weighed 57.7 g, m.p. 80 - 120 °C.
Although this melting range goes above that of the pure comound 0.45 of crude material dissolved in 90 ml. of hot acetone gave 0.40 g of pure compoundd melting at 93 - 95 °C. Other samples of crude piperidone hydrochloride showed even higher melting points than the one mentioned above, yet this apperently impure material always gave good yields of sharp melting product when recrystallized. | [Purification Methods]
It is best purified by fractional distillation The hydrochloride of the hydrate (4-diol) has m 94.7-95.5o, but the anhydrous hydrochloride which crystallises from CHCl3/Et2O has m 165-168o (164-167o) and can also be obtained by sublimation at 120o/2mm. The oxime has m 130-132o (from Me2CO). The methiodide crystallises from MeOH, the crystals with 1MeOH have m 189-190o, and the solvent-free iodide has m 202-204o(dec). [Lyle et al. J Org Chem 24 342 1959, Bowden & Greeen J Chem Soc 1164 1952, Tomita Yakugaku Zasshi (J Pharm Soc Japan) 71 1053 1951, Beilstein 21 IIII/IV 3183, 21/6 V 419.] | [References]
[1] Robert E. Lyle, Laurence Ladd, Richard Munk. “The Asinger Reaction with 1-Methyl-4-piperidone.” The Journal of Organic Chemistry 30 1 (1965): 293–294.
[2] Wildau, Martha. “Ein acidimetrisches Bestimmungsverfahren alkylsubstituierter 1-Methyl-4-piperidone.” Analytical and Bioanalytical Chemistry 147 3 (1955): 231–231.
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