ChemicalBook CAS DataBase List 6-Hydroxypurine

6-Hydroxypurine synthesis

7synthesis methods

Product Name:6-Hydroxypurine
CAS Number:68-94-0
Molecular formula:C5H4N4O
Molecular Weight:136.11

7440-02-0 Synthesis

7440-02-0
416 suppliers
$14.39/1slug

69-89-6 Synthesis

69-89-6
481 suppliers
$6.00/1g

68-94-0
664 suppliers
$5.00/100mg

Yield:68-94-0 1.37 g (67.2%)

Reaction Conditions:

with acetic acid in methanol;propan-1-ol;ethyl acetate;

Steps:

11.C C.

2.18 g (4.5 mM) of xanthine (B.) and 2.6 g of Raney-nickel (treated with 0.1% aqueous acetic acid) were refluxed in 30 ml of 1-propanol for 2.5 hr. The nickel was filtered off and the solution evaporated in vacuo to dryness. The residue was dissolved in 40 ml of ethyl acetate and extracted with sodium bicarbonate solution. The formed solid is filtered off and the organic phase evaporated in vacuo to dryness (1.95 g). A dichloromethane solution, comprising 2% of methanol, was purified on 19 g of silicagel in a column. Crystallization from ethyl acetate gave 1.37 g (67.2%) of hypoxanthine with mp 159-161° C., a second crop gave 0.4 g (2.0%) of hypoxanthine.

References:

US6413975,2002,B1

890-38-0 Synthesis