6-Mercaptopurine monohydrate synthesis
- Product Name:6-Mercaptopurine monohydrate
- CAS Number:6112-76-1
- Molecular formula:C5H6N4OS
- Molecular Weight:170.19
Yield:6112-76-1 83.28%
Reaction Conditions:
with formic acid in ethanol at 78 - 80; for 1 h;
Steps:
1.1
dd to a 50 mL three-necked flask6-chloropurine 5.00g (32.35mmol)And thiourea 2.95g (38.82mmol),Thiolation using absolute ethanol as solvent,Use formic acid as a catalyst to raise the temperature to 78 80 and reflux for 1 h. The reaction is complete.Add the system to a saturated aqueous sodium hydroxide solution,And gradually add glacial acetic acid,White floes appear,Add an appropriate amount of distilled water,After stirring for 1 to 2 hours, a pale yellow powdery substance was obtained after filtering.Dried to obtain 4.1g of light yellow powder,The yield was 83.28%
References:
Guizhou University;Hu Deyu;Wu Fang;Song Baoan;Xue Wei;Jin Linhong;Chen Xuewen;Gan Xiuhai;Li Xiangyang CN104628726, 2016, B Location in patent:Paragraph 0057; 0058; 0059