1H-Imidazol-5-amine,1-methyl-4-nitro-(9CI) synthesis
- Product Name:1H-Imidazol-5-amine,1-methyl-4-nitro-(9CI)
- CAS Number:4531-54-8
- Molecular formula:C4H6N4O2
- Molecular Weight:142.12
4897-25-0
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4531-54-8
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Yield: 91%
Reaction Conditions:
with ammonia in methanol at 100; for 16 h;Autoclave;
Steps:
9.1 Step 1 to synthesize compound 13
A mixture of 5-chloro-l-methyl-4-nitro-imidazole (2 g, 12.38 mmol) in NTb/MeOH (10 mL, 7 M) was stirred at 100°C for 16 hr in an autoclave. The mixture was cooled down to room temperature, and the precipitation was filtered, washed with MeOH (10 mL x 2), dried to afford 3-methyl-5-nitro-imidazol-4-amine (1.6 g, 11.26 mmol, 91% yield) as a yellow solid. NMR (400 MHz, DMSO-^e): d = 7.55 (s, 2H), 7.25 (s, 1H), 3.47 (s, 3H).
References:
BRIDGENE BIOSCIENCES, INC.;CAO, Ping;ZHANG, Chao;BISHOP, Michael, J. WO2020/168237, 2020, A1 Location in patent:Paragraph 00180; 00181
19183-15-4
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4531-54-8
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
3034-41-1
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4531-54-8
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