中文名：TRAM-34,K Ca 3.1通道阻滯劑

英文名：TRAM-34

中文別名：1-[(2-氯苯基)二苯甲基]-1H-吡唑

英文別名：TRAM-34|289905-88-0|1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole|1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole|Tram 34|TRAM34|Triarylmethane-34|C22H17ClN2|1-[(2-chlorophenyl)-diphenylmethyl]pyrazole|CHEMBL498270|CHEBI:34990|1H-Pyrazole, 1-[(2-chlorophe

純度：≥98%

貨號：T129575

包裝：100mg、25mg、5mg

Cas號：289905-88-0

存儲溫度：-20°C儲存

產(chǎn)品介紹：

TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase.TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.

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