UNC0638
|
- $48 - $2395.3
- Product name: UNC0638
- CAS: 1255580-76-7
- MF: C30H47N5O2
- MW: 509.73
- EINECS:
- MDL Number:
- Synonyms:UNC0638;UNC0638/UNC-0638;2-Cyclohexyl-N-(1-isopropyl-4-piperidinyl)-6-Methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;UNC0638 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-cyclohexyl-6-methoxy-n-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine;CS-565;4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
22 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- ManufacturerAK Scientific
- Product number3615DG
- Product descriptionUnc-0638
- Packaging10mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3615DG
- Product descriptionUnc-0638
- Packaging1mg
- Price$151
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1914
- Product descriptionUNC0638
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1889
- Product descriptionUNC0638 98%
- Packaging25mg
- Price$478.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181177
- Product descriptionUNC-0638 >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181177
- Product descriptionUNC-0638 >98%
- Packaging250mg
- Price$1283.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181177
- Product descriptionUNC-0638 >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10734
- Product descriptionUNC0638 ≥98%
- Packaging1mg
- Price$48
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10734
- Product descriptionUNC0638 ≥98%
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10734
- Product descriptionUNC0638 ≥98%
- Packaging10mg
- Price$210
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10734
- Product descriptionUNC0638 ≥98%
- Packaging50mg
- Price$936
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM142748
- Product description2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98%
- Packaging100mg
- Price$383
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2035
- Product descriptionUNC0638 99.73%
- Packaging100mg
- Price$528
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2035
- Product descriptionUNC0638 99.73%
- Packaging50mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2035
- Product descriptionUNC0638 99.73%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2035
- Product descriptionUNC0638 99.73%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3615DG | Unc-0638 | 10mg | $330 | 2021-12-16 | Buy |
| AK Scientific | 3615DG | Unc-0638 | 1mg | $151 | 2021-12-16 | Buy |
| ApexBio Technology | A1914 | UNC0638 | 50mg | $350 | 2021-12-16 | Buy |
| Axon Medchem | Axon1889 | UNC0638 98% | 25mg | $478.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181177 | UNC-0638 >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181177 | UNC-0638 >98% | 250mg | $1283.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181177 | UNC-0638 >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
| Cayman Chemical | 10734 | UNC0638 ≥98% | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 10734 | UNC0638 ≥98% | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 10734 | UNC0638 ≥98% | 10mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 10734 | UNC0638 ≥98% | 50mg | $936 | 2024-03-01 | Buy |
| Chemenu | CM142748 | 2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98% | 100mg | $383 | 2021-12-16 | Buy |
| ChemScene | CS-2035 | UNC0638 99.73% | 100mg | $528 | 2021-12-16 | Buy |
| ChemScene | CS-2035 | UNC0638 99.73% | 50mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-2035 | UNC0638 99.73% | 10mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-2035 | UNC0638 99.73% | 5mg | $72 | 2021-12-16 | Buy |
Properties
Melting point :93-94℃
Boiling point :610.2±55.0 °C(Predicted)
Density :1.124±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≥25.5 mg/mL in DMSO; insoluble in H2O; ≥48.2 mg/mL in EtOH
form :solid
pka :10.07±0.20(Predicted)
color :White to yellow
Boiling point :610.2±55.0 °C(Predicted)
Density :1.124±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≥25.5 mg/mL in DMSO; insoluble in H2O; ≥48.2 mg/mL in EtOH
form :solid
pka :10.07±0.20(Predicted)
color :White to yellow
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of <15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effects. See the Structural Genomics Consortium (SGC) website for more information.Related product price
- CB92592812
$38-665 - UNC-0642
$36-1946 - UNC2025
$60-1700
