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ChemicalBook >> CAS DataBase List >> 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline price.
  • $28 - $2245.7
  • Product name: 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
  • CAS: 356559-20-1
  • MF: C21H21N5
  • MW: 343.42
  • EINECS:
  • MDL Number:MFCD11045307
  • Synonyms:SB-525334;6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline;6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;SB522334;SB525334 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;6-(2-tert-butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl)quinoxaline;6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline SB 525334;SB 525334 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
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Package
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  • 50
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberX7491
  • Product description6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
  • Packaging100mg
  • Price$293
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7491
  • Product description6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
  • Packaging250mg
  • Price$590
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7491
  • Product description6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
  • Packaging500mg
  • Price$927
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA187949
  • Product descriptionSB-525334 98+%
  • Packaging5mg
  • Price$43
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA187949
  • Product descriptionSB-525334 98+%
  • Packaging10mg
  • Price$56
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA187949
  • Product descriptionSB-525334 98+%
  • Packaging50mg
  • Price$94
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA187949
  • Product descriptionSB-525334 98+%
  • Packaging100mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA187949
  • Product descriptionSB-525334 98+%
  • Packaging250mg
  • Price$297
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA187949
  • Product descriptionSB-525334 98+%
  • Packaging1g
  • Price$744
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0008600
  • Product descriptionSB-525334 95.00%
  • Packaging10MG
  • Price$260.4
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0008600
  • Product descriptionSB-525334 95.00%
  • Packaging1G
  • Price$1501.5
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA5602
  • Product descriptionSB525334
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5602
  • Product descriptionSB525334
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5602
  • Product descriptionSB525334
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5602
  • Product descriptionSB525334
  • Packaging25mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5602
  • Product descriptionSB525334
  • Packaging100mg
  • Price$480
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7491 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 100mg $293 2021-12-16 Buy
AK Scientific X7491 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 250mg $590 2021-12-16 Buy
AK Scientific X7491 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 500mg $927 2021-12-16 Buy
Ambeed A187949 SB-525334 98+% 5mg $43 2021-12-16 Buy
Ambeed A187949 SB-525334 98+% 10mg $56 2021-12-16 Buy
Ambeed A187949 SB-525334 98+% 50mg $94 2021-12-16 Buy
Ambeed A187949 SB-525334 98+% 100mg $150 2021-12-16 Buy
Ambeed A187949 SB-525334 98+% 250mg $297 2021-12-16 Buy
Ambeed A187949 SB-525334 98+% 1g $744 2021-12-16 Buy
American Custom Chemicals Corporation KIN0008600 SB-525334 95.00% 10MG $260.4 2021-12-16 Buy
American Custom Chemicals Corporation KIN0008600 SB-525334 95.00% 1G $1501.5 2021-12-16 Buy
ApexBio Technology A5602 SB525334 1unit $28 2021-12-16 Buy
ApexBio Technology A5602 SB525334 5mg $50 2021-12-16 Buy
ApexBio Technology A5602 SB525334 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A5602 SB525334 25mg $150 2021-12-16 Buy
ApexBio Technology A5602 SB525334 100mg $480 2021-12-16 Buy

Properties

Melting point :159 °C
Boiling point :540.5±45.0 °C(Predicted)
Density :1.191
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :10.24±0.10(Predicted)
form :Yellow solid
color :yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :DKPQHFZUICCZHF-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression. It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis. SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.

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