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ChemicalBook >> CAS DataBase List >> GW788388

GW788388

GW788388 price.
  • $57 - $3024
  • Product name: GW788388
  • CAS: 452342-67-5
  • MF: C25H23N5O2
  • MW: 425.48
  • EINECS:
  • MDL Number:MFCD16038936
  • Synonyms:4-[4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl]-N-(tetrahydropyran-4-yl)benzamide;N-(oxan-4-yl)-4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}benzaMide;GW 788388 4-[4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl]-N-(tetrahydropyran-4-yl)benzamide;GW 788388;BenzaMide, 4-[4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-;4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide;GW788388;GW 788388;GW 788388, >=98%
24 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
Package
  • 5mg
  • 10
  • 1mg
  • 10MG
  • 50
  • 25mg
  • 50mg
  • 100mg
  • 10mM(in 1mL DMSO)
  • 250mg
  • 1000mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7615
  • Product description4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
  • Packaging250mg
  • Price$1887
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001485
  • Product descriptionGW-788388 95.00%
  • Packaging10MG
  • Price$267.75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8301
  • Product descriptionGW788388
  • Packaging10mM(in 1mL DMSO)
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181015
  • Product descriptionGW788388 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181015
  • Product descriptionGW788388 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181015
  • Product descriptionGW788388 >98%
  • Packaging1000mg
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16255
  • Product descriptionGW 788388 ≥98%
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16255
  • Product descriptionGW 788388 ≥98%
  • Packaging5mg
  • Price$104
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16255
  • Product descriptionGW 788388 ≥98%
  • Packaging10mg
  • Price$166
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16255
  • Product descriptionGW 788388 ≥98%
  • Packaging25mg
  • Price$315
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM175691
  • Product description4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide 98%
  • Packaging100mg
  • Price$340
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0254
  • Product descriptionGW788388 99.91%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0254
  • Product descriptionGW788388 99.91%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0254
  • Product descriptionGW788388 99.91%
  • Packaging50mg
  • Price$312
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0254
  • Product descriptionGW788388 99.91%
  • Packaging100mg
  • Price$468
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001866
  • Product descriptionGW788388 98+%
  • Packaging50mg
  • Price$318
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7615 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide 250mg $1887 2021-12-16 Buy
American Custom Chemicals Corporation INB0001485 GW-788388 95.00% 10MG $267.75 2021-12-16 Buy
ApexBio Technology A8301 GW788388 10mM(in 1mL DMSO) $70 2021-12-16 Buy
Biorbyt Ltd orb181015 GW788388 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181015 GW788388 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb181015 GW788388 >98% 1000mg $2245.7 2021-12-16 Buy
Cayman Chemical 16255 GW 788388 ≥98% 1mg $57 2024-03-01 Buy
Cayman Chemical 16255 GW 788388 ≥98% 5mg $104 2024-03-01 Buy
Cayman Chemical 16255 GW 788388 ≥98% 10mg $166 2024-03-01 Buy
Cayman Chemical 16255 GW 788388 ≥98% 25mg $315 2024-03-01 Buy
Chemenu CM175691 4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide 98% 100mg $340 2021-12-16 Buy
ChemScene CS-0254 GW788388 99.91% 5mg $72 2021-12-16 Buy
ChemScene CS-0254 GW788388 99.91% 10mg $108 2021-12-16 Buy
ChemScene CS-0254 GW788388 99.91% 50mg $312 2021-12-16 Buy
ChemScene CS-0254 GW788388 99.91% 100mg $468 2021-12-16 Buy
Crysdot CD31001866 GW788388 98+% 50mg $318 2021-12-16 Buy

Properties

Density :1.34
storage temp. :2-8°C
solubility :Soluble in DMSO (18 mg/ml with warming)
form :solid
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GW 788388 is a selective inhibitor of transforming growth factor-β (TGF-β) type 1 receptor (TGFBR1 or ALK5; IC50 = 18 nM). It inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day. As TGF-β stimulates fibrosis in a range of tissues, GW 788388 reduces typical features of fibrosis, including tissue remodeling, increased expression of α-smooth muscle actin and production of collagen I. GW 788388 also blocks TGF-β-mediated production of VEGF by fibroblasts, as well as subsequent angiogenesis in vitro. Inhibition of ALK5 signaling by GW 788388 also induces hypertrophy in femoral growth plates in rats.

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