ネファゾドン
ネファゾドン 物理性質(zhì)
- 融點(diǎn) :
- 186-188°C
- 貯蔵溫度 :
- Inert atmosphere,Room Temperature
- 溶解性:
- DMSO：11mg/mL、60℃
- 外見(jiàn) :
- 個(gè)體
- 色:
- 白い
- 極大吸収波長(zhǎng) (λmax):
- 248nm(MeOH)(lit.)
- Merck :
- 14,6438
- CAS データベース:
- 82752-99-6(CAS DataBase Reference)
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
| Sフレーズ |
22-24/25 |
|
|
| RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
|
|
| WGK Germany |
3 |
|
|
| RTECS 番號(hào) |
XZ5483009 |
|
|
| HSコード |
2933595960 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語(yǔ) |
警告 |
| 危険有害性情報(bào) |
| コード |
危険有害性情報(bào) |
危険有害性クラス |
區(qū)分 |
注意喚起語(yǔ) |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強(qiáng)い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標(biāo)的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書(shū)き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P305+P351+P338 |
眼に入った場(chǎng)合：水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場(chǎng)合は外す こと。その後も洗浄を続けること。 |
|
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQA-4240 |
ネファゾドン HCl
Nefazodone HCl |
82752-99-6 |
1g |
￥30000 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQA-4240 |
ネファゾドン HCl
Nefazodone HCl |
82752-99-6 |
5g |
￥100000 |
2024-03-01 |
購(gòu)入 |
|
東京化成工業(yè)
|
N1030 |
ネファゾドン塩酸塩 >98.0%(HPLC)(T)
Nefazodone Hydrochloride
>98.0%(HPLC)(T) |
82752-99-6 |
200mg |
￥6500 |
2024-03-01 |
購(gòu)入 |
|
東京化成工業(yè)
|
N1030 |
ネファゾドン塩酸塩 >98.0%(HPLC)(T)
Nefazodone Hydrochloride
>98.0%(HPLC)(T) |
82752-99-6 |
1g |
￥21300 |
2024-03-01 |
購(gòu)入 |
|
Sigma-Aldrich Japan
|
1457902 |
ネファゾドン 塩酸塩 United States Pharmacopeia (USP) Reference Standard
Nefazodone hydrochloride United States Pharmacopeia (USP) Reference Standard |
82752-99-6 |
200mg |
￥161000 |
2024-03-01 |
購(gòu)入 |
ネファゾドン 化學(xué)特性,用途語(yǔ),生産方法
外観
白色～ほとんど白色粉末～結(jié)晶
効能
抗うつ薬
説明
Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT
2 receptor antagonist
and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to
enhance 5-HT
IA-mediated neurotransmission. Distinct from the first generation
agents such as tricyclic antidepressants, nefazodone has very selective
serotonergic effects with negligible affinity for cholinergic and histamine receptors,
and low affinity for a
1 -adrenergic receptors. Therefore, it has a superior toxicity
profile that does not produce agitation, insomnia, and lacks cardiac side effects.
化學(xué)的特性
White Solid
使用
A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
一般的な説明
Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike
; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
生物活性
Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.
ネファゾドン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
ネファゾドン 生産企業(yè)
Global( 222)Suppliers
82752-99-6(ネファゾドン)キーワード:
- 82752-99-6
- NEFAZODONE-D5 HCL
- 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
- Nefazodone HCl
- Nefazodone hydrochloride
- NEFAZODONE
- BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
- 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
- Nefazodone Hydrochloride (200 mg)
- 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
- BMY 13754-1
- Serazone
- Nefazodone hydrochloride API
- 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride
- Nefazodone hydrochlo
- 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-
- >=98% (HPLC)
- 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4
- )-trans-4-(3-cyanophenyl)pyrrolidine-3-carboxylic acid &ge
- 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate &ge
- Na-Fmoc-Nb-(N-Boc-amino-oxyacetyl)-L-2,3-diaminopropionic acid &ge
- Fmoc-1-amino-4-oxo-cyclohexane carboxylic acid &ge
- 8-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione &ge
- Fmoc-D-2-amino-4-bromo-4-pentenoic acid &ge
- 2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole &ge
- 3-(4-Methoxyphenyl)pyrazole &ge
- Boc-N-ethyl glycine &ge
- Boc-D-a-aminobutyric acid &ge
- Na-Fmoc-Ne-Z-L-lysine &ge
- (1,2-Dibromoethyl)benzene &ge
- Na-Acetyl-L-ornithine &ge
- ネファゾドン塩酸塩
- 2-[3-[4-(3-クロロフェニル)-1-ピペラジニル]プロピル]-5-エチル-2,4-ジヒドロ-4-(2-フェノキシエチル)-3H-1,2,4-トリアゾール-3-オン塩酸塩
- ネフアゾドン塩酸塩
- ネファゾドン HCL
- ネファゾドン 塩酸塩