Nefazodone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT₂ receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HT_IA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a₁ -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.

Chemische Eigenschaften

White Solid

Verwenden

A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.

Allgemeine Beschreibung

Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike^; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.

Biologische Aktivit?t

Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.

Nefazodone hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Nefazodone hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15352	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58

82752-99-6()Verwandte Suche:

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• NEFAZODONE-D5 HCL
• 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
• Nefazodone HCl
• Nefazodone hydrochloride
• NEFAZODONE
• BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
• 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
• Nefazodone Hydrochloride (200 mg)
• 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
• BMY 13754-1
• Serazone
• Nefazodone hydrochloride API
• 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride
• Nefazodone hydrochlo
• 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-
• >=98% (HPLC)
• 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4
• )-trans-4-(3-cyanophenyl)pyrrolidine-3-carboxylic acid &ge
• 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate &ge
• Na-Fmoc-Nb-(N-Boc-amino-oxyacetyl)-L-2,3-diaminopropionic acid &ge
• Fmoc-1-amino-4-oxo-cyclohexane carboxylic acid &ge
• 8-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione &ge
• Fmoc-D-2-amino-4-bromo-4-pentenoic acid &ge
• 2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole &ge
• 3-(4-Methoxyphenyl)pyrazole &ge
• Boc-N-ethyl glycine &ge
• Boc-D-a-aminobutyric acid &ge
• Na-Fmoc-Ne-Z-L-lysine &ge
• (1,2-Dibromoethyl)benzene &ge
• Na-Acetyl-L-ornithine &ge
• Na-Acetyl-D-tryptophan &ge
• 5,6-Dimethoxyindole &ge
• Z-L-serine amide &ge
• TFA &ge
• Gly-OBg·
• Boc-4-iodo-L-phenylalanine &ge
• Boc-S-tert-butyl-L-cysteine dicyclohexylammonium salt &ge
• D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid &ge
• (3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester hydrochloride &ge
• 4-Acetamido-2-methylbenzoic acid &ge
• Methyl 2,4-dioxo-4-(2-thienyl)butanoate &ge
• 3-(4-Fluorophenyl)-1H-pyrazole-5-carbohydrazide &ge
• (3-Benzothienyl)-L-b-homoalanine hydrochloride &ge
• 2-(2H-Tetrazol-5-yl)pyridine &ge
• (S)-Fmoc-3-amino-2-benzyl-propionic acid &ge
• 7-Methoxy-1H-indole-3-carbaldehyde &ge
• 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine &ge
• 5-Amino-2-methylpyridine &ge
• Ethyl 3-Amino-3-ethoxyacrylate hydrochloride &ge
• Fmoc-(4-aminomethyl) benzoic acid &ge
• Fmoc-3,4-dichloro-L-b-homophenylalanine &ge
• 1,3-Diacetylindole &ge
• Fmoc-3-nitro-D-phenylalanine &ge
• 4-Amino-D-phenylalanine hydrochloride &ge
• Fmoc-(R)-4-aminopimelic acid 1-tert-butyl ester &ge
• 5-Azacytidine &ge
• 1-(2-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbohydrazide &ge
• 5-(4-Bromophenyl)thiophene-2-carboxylic acid &ge