ネファゾドン 化學(xué)特性,用途語(yǔ),生産方法
効能
抗うつ薬
化學(xué)的特性
Crystalline Solid
使用
A selective serotonin 5-HT2 receptor antagonist. An antidepressant
生物學(xué)の機(jī)能
Although nefazodone (Serzone) is structurally related
to trazodone, it is less sedating. It does not block α
1-
adrenoreceptors, and its use is not associated with priapism.
Nefazodone inhibits the neuronal reuptake of
serotonin and blocks 5HT2A receptors. Its short half-life
requires dosing twice a day. Nefazodone is
not associated with weight gain or sexual dysfunction. It
inhibits the cytochrome P450 3A4 isoenzyme that is responsible
for 50% of known oxidative metabolism, and
therefore, nefazodone can elevate levels of drugs dependent
on this pathway for metabolism.
ネファゾドン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品