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Diflunisal

Diflunisal Struktur
22494-42-4
CAS-Nr.
22494-42-4
Bezeichnung:
Diflunisal
Englisch Name:
Diflunisal
Synonyma:
mk647;Adomal;MK 647;Dolisal;Dolobid;Dolobil;Dolobis;Flustar;Difludol;Flovacil
CBNumber:
CB9674965
Summenformel:
C13H8F2O3
Molgewicht:
250.2
MOL-Datei:
22494-42-4.mol

Diflunisal Eigenschaften

Schmelzpunkt:
207-209?C
Siedepunkt:
386.9±42.0 °C(Predicted)
Dichte
1.3505 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
L?slichkeit
Practically insoluble in water, soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
Aggregatzustand
Solid
pka
pKa 3.3 (H2O I=0.1) (Uncertain)
Farbe
White
Wasserl?slichkeit
6.186mg/L(24.99 ºC)
CAS Datenbank
22494-42-4(CAS DataBase Reference)
NIST chemische Informationen
Diflunisal(22494-42-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 22-36/37/38-63
S-S?tze: 22-26-36
WGK Germany  3
RTECS-Nr. DV2030000
Hazard Note  Irritant
HS Code  2918290000
Toxizit?t LD50 orally in female mice: 439 mg/kg (Stone)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Diflunisal Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Diflunisal is more potent than aspirin but produces fewer side effects and has a biological half-life three to four times greater than that of aspirin. It is rapidly and completely absorbed on oral administration, with peak plasma levels being achieved within 2 to 3 hours of administration. It is highly bound (99%) to plasma proteins after absorption. Its elimination half-life is 8 to 12 hours, and it is excreted into urine primarily as glucuronide conjugates. The most frequently reported side effects include disturbances of the GI system (e.g., nausea, dyspepsia, and diarrhea), dermatological reactions, and CNS effects (e.g., dizziness and headache).

Chemische Eigenschaften

White Solid

Verwenden

As a prostaglandin synthetase inhibitor, diflunisal exhibits analgesic, fever-reducing, and anti-inflammatory action. It is used for long- and short-lasting symptomatic relief of low to moderate pain in osteoarthritis and rheumatoid arthritis.

Allgemeine Beschreibung

Diflunisal (Dolobid), is a longer acting and more potent drugthan aspirin because of its hydrophobic, 2,4-difluorophenylgroup attached to the 5-position of the salicyclic acid. In alarge-scale comparative study with aspirin, it was also bettertolerated with less GI complications than aspirin. It ismarketed in tablet form for treating mild to moderate postoperativepain as well as RA and OA.
Diflunisal is highly protein bound. Its metabolism is subjectto a dose-dependent, saturable, and capacity-limitedglucuronide formation. This unusual pharmacokineticprofile is a result of an enterohepatic circulation and the reabsorptionof 65% of the drug and its glucuronides, followedby cleavage of its unstable, acyl glucuronide back tothe active drug. Thus, diflunisal usage in patients with renalimpairment should be closely monitored.

Pharmakokinetik

Diflunisal is more potent than aspirin but produces fewer side effects and has a biological half-life three to four times greater than that of aspirin. It is rapidly and completely absorbed on oral administration, with peak plasma levels being achieved within 2 to 3 hours of administration. It is highly bound (99%) to plasma proteins after absorption. Its elimination half-life is 8 to 12 hours, and it is excreted into urine primarily as glucuronide conjugates. The most frequently reported side effects include disturbances of the GI system (e.g., nausea, dyspepsia, and diarrhea), dermatological reactions, and CNS effects (e.g., dizziness and headache).

Clinical Use

Diflunisal (pKa 3.3) was introduced in the United States in 1982 and has gained considerable acceptance as an analgetic and as a treatment of rheumatoid arthritis and osteoarthritis. Diflunisal is metabolized primarily to ether and ester glucuronide conjugates.

Sicherheitsprofil

Poison by ingestion, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: tolerance, and cholestatic jaundce (due to the stoppage of the flow of bile), agranulocytosis, increased body temperature. An experimental teratogen. Other experimental reproductive effects. An analgesic and anti-inflammatory agent. When heated to decomposition it emits toxic fumes of F-. See also FLUORIDES.

Diflunisal Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diflunisal Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 266)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 904 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
+8615377521700
wangwendy93@gmail.com China 868 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
+86-027-81302088 +86-13986076795
Circlepowder02@163.com CHINA 279 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 7629 58

22494-42-4(Diflunisal)Verwandte Suche:


  • DIFLUSINAL
  • LABOTEST-BB LT00771921
  • 2',4'-DIFLUORO-4-HYDROXY[1,1'-BIPHENYL]-3-CARBOXYLIC ACID
  • 2',4'-DIFLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
  • 5-[2,4-DIFLUOROPHENYL]SALICYLIC ACID
  • [1,1'-Biphenyl]-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-
  • 1’-biphenyl)-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-(
  • 1’-biphenyl]-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-[
  • 2-(Hydroxy)-5-(2,4-difluorophenyl)benzoic acid
  • 2-(hydroxy)-5-(2,4-difluorophenyl)benzoicacid
  • 2',4'-Difluoro-4-hydroxy-(1',1-diphenyl)-3-carboxylic acid
  • 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid
  • 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicaci
  • 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicacid
  • 3-Biphenylcarboxylic acid, 2',4'-difluoro-4-hydroxy-
  • Adomal
  • Difludol
  • Dolisal
  • Dolobid
  • Dolobil
  • Dolobis
  • Flovacil
  • Fluniget
  • Fluodonil
  • Flustar
  • MK 647
  • mk647
  • DIFLUCORTOLONE
  • 5-(2,4-Difluorophenyl)-2-hydroxybenzoic acid
  • Diflunisal
  • Diflunisal,5-(2,4-Difluorophenyl)salicylic acid
  • Diflunisal (200 mg)
  • DIFLUNISAL,USP
  • 5-(2,4-DIFLUOROPHENYL)SALICYLICACID(DIFLUNISAL)
  • 2',4'-Difluoro-4-hydroxy-
  • Diflunusal
  • Diflunisal,DOLOBID, Dolisal, Dorbid, Dugodol, MK-647, Donobid
  • Diflunisa
  • Diflunisal CRS
  • Diflunisal USP/EP/BP
  • Diflunisal-13C6
  • DiflunisalQ: What is Diflunisal Q: What is the CAS Number of Diflunisal Q: What is the storage condition of Diflunisal Q: What are the applications of Diflunisal
  • Diflunisal (1197506)
  • Diflunix
  • 2',4'-Difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • 13C6]-Diflisal
  • 2’,4’-Difluoro-4-hydroxybiphenyl-3-carboxylic Acid
  • Diflunisal in Acetonitrile
  • Tenofovir Alafenamide Impurity 93
  • 22494-42-4
  • C13H8F2O3
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  • Analytical Chromatography Product Catalog
  • Analytical Standards
  • DOLOBID
  • Aromatics
  • Fluorescent Labels & Indicators
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