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Baclofen

Baclofen Struktur
1134-47-0
CAS-Nr.
1134-47-0
Bezeichnung:
Baclofen
Englisch Name:
Baclofen
Synonyma:
ofen;Clofen;baclon;Spinax;Lioresa;ba34647;Atrofen;c34647ba;BACLOFEN;LIORESAL
CBNumber:
CB8669450
Summenformel:
C10H12ClNO2
Molgewicht:
213.66
MOL-Datei:
1134-47-0.mol

Baclofen Eigenschaften

Schmelzpunkt:
208-210°C
Siedepunkt:
364.3±32.0 °C(Predicted)
Dichte
1.2069 (rough estimate)
Brechungsindex
1.5500 (estimate)
storage temp. 
2-8°C
L?slichkeit
1 M HCl: 50 mg/mL
Aggregatzustand
solid
pka
pKa 3.87±0.1(H2O) (Uncertain)
Farbe
white to very faintly yellow
Wasserl?slichkeit
Soluble in dilute NaOH or dilute HCl. Soluble in water at approximately 4mg/ml at pH 7.6
Merck 
14,937
Stabilit?t:
Hygroscopic
InChI
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey
KPYSYYIEGFHWSV-UHFFFAOYSA-N
SMILES
C1(C=CC(Cl)=CC=1)C(CN)CC(=O)O
CAS Datenbank
1134-47-0(CAS DataBase Reference)
NIST chemische Informationen
Baclofen(1134-47-0)
EPA chemische Informationen
.beta.-(Aminomethyl)-4-chlorobenzenepropanoic acid (1134-47-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T,Xn
R-S?tze: 61-25-36/37/38-42/43-20/21/22
S-S?tze: 53-22-36/37/39-45-52-36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. MW5084200
HazardClass  6.1(b)
PackingGroup  III
HS Code  2922492050
Toxizit?t LD50 in male mice, rats (mg/kg): 45, 78 i.v.; 103, 115 s.c.; 200, 145 orally (Tadokoro)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit

Baclofen Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R61:Kann das Kind im Mutterleib sch?digen.
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S52:Nicht gro?fl?chig für Wohn- und Aufenthaltsr?ume zu verwenden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Off-White Solid

Verwenden

Baclofen may be used as a pharmaceutical secondary reference standard for the determination of the analyte in plasma samples by liquid chromatography tandem mass spectrometry and tablet formulations by UV spectroscopy, respectively.

Definition

ChEBI: A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.

Biologische Funktion

Baclofen (Lioresal) is the parachlorophenol analogue of the naturally occurring neurotransmitter γ-aminobutyric acid (GABA).

Allgemeine Beschreibung

Odorless or practically odorless white to off-white crystalline powder.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

Baclofen is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Brandgefahr

Flash point data for Baclofen are not available. Baclofen is probably combustible.

Biologische Aktivit?t

Selective GABA B receptor agonist. Skeletal muscle relaxant.

Mechanism of action

Baclofen appears to affect the neuromuscular axis by acting directly on sensory afferents, γ-motor neurons, and collateral neurons in the spinal cord to inhibit both monosynaptic and polysynaptic reflexes. The principal effect is to reduce the release of excitatory neurotransmitters by activation of presynaptic GABAB receptors. This seems to involve a G protein and second-messenger link that either increases K+ conductance or decreases Ca++ conductance.

Clinical Use

Baclofen is an agent of choice for treating spinal spasticity and spasticity associated with multiple sclerosis. It is not useful for treating spasticity of supraspinal origin. Doses should be increased gradually to a maximum of 100 to 150 mg per day, divided into four doses.

Nebenwirkungen

Side effects are not a major problem, and they can be minimized by graduated dosage increases.They include lassitude, slight nausea, and mental disturbances (in including confusion, euphoria, and depression). The drowsiness is less pronounced than that produced by diazepam—an important therapeutic advantage. Hypotension has been noted, particularly following overdose. Elderly patients and patients with multiple sclerosis may require lower doses and may display increased sensitivity to the central side effects. Baclofen may increase the frequency of seizures in epileptics.

Sicherheitsprofil

Poison by ingestion,subcutaneous and intravenous routes. Human systemiceffects by ingestion: blood pressure lowering, coma,muscle weakness, pulse rate decrease, respiratorydepression. When heated to decomposition it emits toxicfumes of Cl-

Stoffwechsel

Baclofen is rapidly and effectively absorbed after oral administration. It is lipophilic and able to penetrate the blood-brain barrier.Approximately 35% of the drug is excreted unchanged in the urine and feces.

Baclofen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Baclofen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 554)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Joyochem Co.,Ltd
+86-0531-82687558 +8613290333633
sales@joyochem.com China 31 58
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 2994 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097
market02@senwayer.com China 904 58
Zibo Wei Bin Import & Export Trade Co. Ltd.
+86-0533-2091136 +8613864437655
ziboweibinmaoyi@163.com China 100 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Anhui Yiao New Material Technology Co., Ltd
+86-18033737140 +86-17354101231
sales1@hbganmiao.com China 227 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58

1134-47-0(Baclofen)Verwandte Suche:


  • 4-Amino-3-(p-chlorophenyl)butyric acid
  • Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
  • CIBA Ba 34647
  • DL-4-Amino-3-p-chlorophenylbutanoic acid
  • DL-Baclofen
  • Hydrocinnamic acid, β-(aminomethyl)-p-chloro- (7CI, 8CI)
  • β-(4-Chlorophenyl)-γ-aminobutyric acid
  • β-p-Chlorophenyl-GABA
  • Baclofen(R)
  • (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
  • g-Amino-b-(p-chlorophenyl)butyric acid
  • Baclofen13C2
  • -(4-Chlorophenyl)-GABA
  • -(Aminomethyl)-4-chloro-benzenepropanoic Acid
  • (±)-Baclofen,(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
  • Baclofen (350 mg)
  • Baclofen (500 mg)
  • β-(Aminomethyl)-4-chlorohydrocinnamic acid
  • Clofen
  • Lioresa
  • Benzenepropanoic acid, .beta.-(aminomethyl)-4-chloro-
  • BACLOFEN,USP
  • Hydrocinnamic acid, b-(aminomethyl)-p-chloro.
  • beta-(aminomethyl)-p-chloro-hydrocinnamicaci
  • beta-(aminomethyl)-p-chlorohydrocinnamicacid
  • beta-(p-chlorophenyl)-gamma-aminobutyricacid
  • c34647ba
  • ciba34,647-ba
  • gamma-amino-beta-(p-chlorophenyl)butyricacid
  • 4-AMino-3-(4-chlorophenyl)butyric Acid, Baclofen
  • Baclofen beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
  • (RS)-4-AMINO-3-(4-CHLOROPHENYL)BUTANOIC ACID
  • (RS)-BACLOFEN
  • -(Aminomethyl)-4-chlorobenzenpropanoicacid
  • -(p-Chlorophenyl)-aminobutyricacid
  • ba34647
  • baclon
  • beta-(4-chlorophenyl)gaba
  • beta-(aminomethyl)-4-chloro-benzenepropanoicaci
  • 4-AMINO-3-[4-CHLOROPHENYL]BUTANOIC ACID
  • 4-AMINO-3(4-CHLOROPHENYL)BUTYRIC ACID
  • (+/-)-BACLOFEN
  • BACLOFEN
  • AURORA KA-6748
  • (+/-)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID
  • (+/-)-BETA-(AMINOETHYL)-4-CHLOROBENZENEPROPANOIC ACID
  • LIORESAL
  • (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
  • Atrofen
  • beta-(4-chlorophenyl)-gamma-aminobutyric acid
  • Beta-(4-Chlorophenyl)-Gaba,Usp
  • (3RS)-4-AMINO-3-(P-CHLOROPHENYL)BUTANOIC ACID
  • (+/-)-BACLOFEN, PHARMA
  • 4-Amino-3-[Chlorophenyl] butanoic acid
  • β-[Aminomethyl]-p-chlorohydrocinnamic acid
  • (+/-)-Baclofen(USPgrade)
  • b-(4-Chlorophenyl)-GABA
  • b-(Aminomethyl)-4-chloro-benzenepropanoic Acid
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