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2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid

Bethanechol Struktur
590-63-6
CAS-Nr.
590-63-6
Bezeichnung:
2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid
Englisch Name:
Bethanechol
Synonyma:
BETHANECHOL CHLORIDE;duvoid;Betanechol;Bthanechol chloride;Mictone;Uro-Carb;Mechotane;Mecothane;NSC 30783;-β-methyL
CBNumber:
CB8156880
Summenformel:
C7H17ClN2O2
Molgewicht:
196.68
MOL-Datei:
590-63-6.mol

2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid Eigenschaften

Schmelzpunkt:
187-190°C
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
H2O: 1.7 g/mL stable for several days at 4°C.
Aggregatzustand
crystalline
Farbe
white
Merck 
14,1185
CAS Datenbank
590-63-6(CAS DataBase Reference)
EPA chemische Informationen
1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (590-63-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 36
WGK Germany  3
RTECS-Nr. BR5425000
TSCA  Yes
HS Code  2924190002
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 μM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC50 = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.

Chemische Eigenschaften

White Solid

Verwenden

cholinergic

Definition

ChEBI: The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.

Allgemeine Beschreibung

Bethanechol, β-methylcholinechloride carbamate, (2-hydroxypropyl)trimethylammoniumchloride carbamate, carbamylmethylcholinechloride (Urecholine), is nonspecific in its action on muscarinicreceptor subtypes but appears to be more effective ateliciting pharmacological action of M3 receptors. It haspharmacological properties similar to those of methacholine.Both are esters of β-methylcholine and have feeblenicotinic activity. Bethanechol is inactivated more slowlyby AChE in vivo than is methacholine. It is a carbamyl esterand is expected to have stability in aqueous solutions similarto that of carbachol.

Hazard

Headache, flushing, gastrointestinal distress, diarrhea, hypotension, excessive salivation, sweating, hypersensitivity.

Mechanism of action

Bentanechol is a drug, which has structurally unique qualities of both methacholine and carbachol, i.e. it contains both β-methyl and carbamate functional groups, and quite logically exhibits pharmacological properties of both the drugs. It is resistant to hydrolysis by cholinesterases and has a very minor effect on nicotinic receptors of the autonomic ganglia and neuromuscular junctions. Betanechol has more of a selective action on muscarinic receptors of the gastrointestinal tract and the bladder than do other cholinic esters.

Clinical Use

The main use of bethanechol chloride is in the relief ofurinary retention and abdominal distention after surgery.The drug is used orally and by subcutaneous injection. Itmust never be administered by intramuscular or intravenousinjection because of the danger from cholinergic overstimulationand loss of selective action. Proper administration ofthe drug is associated with low toxicity and no serious sideeffects. Bethanechol chloride should be used with caution inasthmatic patients; when used for glaucoma, it producesfrontal headaches from the constriction of the sphinctermuscle in the eye and from ciliary muscle spasms. Its durationof action is 1 hour.

2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 373)Lieferanten
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Hebei Mojin Biotechnology Co., Ltd
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010-60279497
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025-83697070
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+86-13734021967 +8613734021967
kaia@neputrading.com China 1001 58

590-63-6(2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid)Verwandte Suche:


  • (2-hydroxypropyl)trimethylammoniumchloridecarbamate
  • 2-((aminocarbonyl)oxy)-n,n,n-trimethyl-1-propanaminiuchloride
  • 2-[(aminocarbonyl)oxy]-n,n,n-trimethyl-1-propanaminiuchloride
  • ammonium,(2-hydroxypropyl)trimethyl-,chloride,carbamate
  • beta-methylcholinechlorideurethan
  • bethainecholinechloride
  • carbaminoyl,beta-methylcholinechloride
  • carbamyl-b-methylcholinechloride*crystalline
  • carbamylmethylcholinechloride
  • mechothane
  • myocholine
  • urecholine
  • urecholinechloride
  • CARBAMYL-BETA-METHYLCHOLINE CHLORIDE
  • Bethanechol chloride USP
  • (2-Hydroxypropyl)trimethylammonium chloride carbamate (6CI)
  • 1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride
  • Ammonium, (2-hydroxypropyl)trimethyl-, chloride, carbamate (8CI)
  • Besacholine
  • b-Methyl carbachol chloride
  • Mechotane
  • Mecothane
  • Mictone
  • Myotonachol
  • Myotonine chloride
  • BETHANECHOL CHLORIDE, PHARMA
  • NSC 30783
  • Trimethyl(2-carbamoyloxypropyl)ammonium chloride
  • Uro-Carb
  • β-Methylcholine chloride urethan
  • 2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium chloride
  • 2-Carbamoyloxypropyltrimethylammonium chloride
  • Bethanechol
  • CARBAMYL-B-METHYLCHOLINECHLORIDE
  • Betaine choline chloride
  • Carbamyl-β-methylcholine chloride,Bethanechol chloride
  • Bethanechol Chloride (200 mg)
  • CarbaMyl-beta-Methylcholine chlori
  • 1-PropanaMiniuM,2-[(aMinocarbonyl)oxy]-N,N,N-triMethyl-, chloride (1:1)
  • 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium,chloride (1:1)
  • 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium chloride
  • 2-(Carbamoyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
  • bisaikelin
  • Bethanechol Chloride >
  • -β-methyL
  • Carbamyl-β-methylcholine chloride
  • Bethanechol USP/EP/BP
  • bethanechol chloride 590-63-6
  • game canling
  • Bethanechol ChlorideQ: What is Bethanechol Chloride Q: What is the CAS Number of Bethanechol Chloride Q: What is the storage condition of Bethanechol Chloride Q: What are the applications of Bethanechol Chloride
  • TIANFU CHEM --Bethanechol
  • duvoid
  • BETHANECHOL CHLORIDE
  • Betanechol
  • Bthanechol chloride
  • Bethanechol Powder USP Standard
  • 2- (Carbamoyl oxy) - N, N, N-trimethyl-1-propanamium chloride
  • 590-63-6
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