Cholinchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
WEISSE HYGROSKOPISCHE KRISTALLE
CHEMISCHE GEFAHREN
Beim Verbrennen Bildung giftiger und ?tzender Rauche mit Chlorwasserstoff. Reagiert mit starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
INHALATIONSGEFAHREN
Eine bel?stigende Partikelkonzentration in der Luft kann beim Dispergieren schnell erreicht werden.
LECKAGE
Verschüttetes Material in Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern.
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White crystalline powder
Application
Choline chloride has been used:
as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
for choline standard curve generation for quantifying phospholipase D (PLD) activity
as a component of slice solution for the dissection of entorhinal-hippocampal brain slices
Definition
ChEBI: Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline.
benefits
choleretic, lipotropic, hepatoprotectant
Allgemeine Beschreibung
Choline chloride appears as white crystals. Practically neutral aqueous solution(NTP, 1992). It is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Air & Water Reaktionen
Deliquescent. Very soluble in water.
Reaktivit?t anzeigen
An acidic organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Brandgefahr
Choline chloride is relatively nonflammable.
Sicherheitsprofil
Poison by
intraperitoneal and intravenous routes.
Moderately toxic experimentally by ingestion
and subcutaneous routes. Mutation data
reported. A lipotropic agent which induces
the reduction in fats contained in the liver.
When heated to decomposition it emits
toxic fumes of Cl-, SOx and NOx. See also
CHOLINE.
l?uterung methode
Extremely deliquescent. Check purity by AgNO3 titration or by titration of OH-base after passage through an anion-exchange column. Crystallise it from absolute EtOH, or EtOH/Et2O, dry it under vacuum and store it in a vacuum desiccator over P2O5 or Mg(ClO4)2. [Beilstein 4 IV 1443.]
Cholinchlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-((Aminocarbonyl)oxy)-N,N,N-tri-methylethan-aminiumchlorid
Feed additives
Acetylcholinchlorid
2-Hydroxy-N,N,N-trimethyl-ethanaminium, Salz mit2-Hydroxybenzoes?ure (1:1)
2-Bromethyltrimethylammoniumbromid
2,2'-(Oxybis(methylen))bis-oxiran
[R-(aLl-Z)]-[4-oxido-10-oxo-7-[(1-oxooctadeca-9,12-dienyl)oxy]-3,5,9-trioxa-4-phosphaheptacosa-18,21-dienyl]trimethylammonium-4-oxid
Trimethyl[2-(phosphonooxy)ethyl]ammoniumchlorid, Calciumsalz (1:1)