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Clofarabine

Clofarabine Struktur
123318-82-1
CAS-Nr.
123318-82-1
Englisch Name:
Clofarabine
Synonyma:
200mg;Clolar;2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine;2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine;CAFDA; Clola;Evoltra;CS-1954;Clofarex;Clorabine
CBNumber:
CB2277491
Summenformel:
C10H11ClFN5O3
Molgewicht:
303.68
MOL-Datei:
123318-82-1.mol

Clofarabine Eigenschaften

Schmelzpunkt:
228-2310C
Siedepunkt:
550.0±60.0 °C(Predicted)
Dichte
1.4804 (estimate)
RTECS-Nr.
UD7473000
storage temp. 
2-8°C
L?slichkeit
DMSO: >10mg/mL
Aggregatzustand
Powder
pka
12.56±0.70(Predicted)
Farbe
white
maximale Wellenl?nge (λmax)
263nm(EtOH)(lit.)
Merck 
14,2372
InChIKey
INHHKRVRRUIAPA-KJHIFWANSA-N
CAS Datenbank
123318-82-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  2
HazardClass  6.1
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Clofarabine Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White Solid

Verwenden

Clofarabine has been used in a cell viability assay to analyze the sensitivity of the isogenic cell lines towards clofarabine. It is also used to study the interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein.

Definition

ChEBI: A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metaboli e, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.

Biologische Aktivit?t

Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

Clofarabine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1234346-14-5 2-Chloro-9-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purin-6-aMine

Downstream Produkte

Clofarabine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 455)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhu Nuowei chemistry Co., Ltd.
+86-0553-2911116-802 +undefined17756524438
 sales1@nuowei-chem.com China 1638 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907
 qinhe02@xaltbio.com China 997 58
Hebei Mojin Biotechnology Co.,Ltd 		+86-15028179902
angelia@hbmojin.com China 1176 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Accela ChemBio Inc. 		+1-858-6993322
info@accelachem.com United States 17777 58
Beijing Ribio Biotech Co.,Ltd 		010-62664360 +8613328773880
 wucy@ribio.com.cn China 117 58
Yunbio Tech Co.,Ltd. 		+86-010-60605551 +86-18046518538
 yunbiochem@126.com China 321 58

123318-82-1()Verwandte Suche:

  • 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
  • 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • CLOFARABINE
  • CAFDA
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine
  • Clofarabine2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE
  • 5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
  • 6-AMino-2-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
  • Clola
  • 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
  • 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
  • CLOFARABINE(FORR&DONLY)
  • CLOFARABINE, 5-(6-AMINO-2-CHLORO-PURIN-9-YL)-4-FLUORO-2-(HYDROXYMETHYL)OXOLAN-3-OL
  • CLORFARABINE
  • (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
  • 2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE (CLOFARABINE)
  • 2-Chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purin-6-amine
  • 50MG/200MG/100G
  • 2-Chloro-6-aMino-purine-2'-fluoro-2'- deoxy arabin
  • (2R,3R,4S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxyMethyl)oxolan-3-ol
  • Clofarabine, Free Base
  • Clofarex
  • Evoltra
  • 6-Amino-2-chloro-9-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)purine
  • CLOLAR CLOFARABINE
  • (2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-Chloro-2-arabino-fluoro-2-deoxyadenosine
  • 6-AMino-2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
  • Clofarabine-13C1-15N3
  • CS-1954
  • Clofarabine >
  • (2R,3R,4S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
  • 6-Amino-2-chloropurine -9-beta-D-(2’-deoxy-2’-fluoro)-arabinoriboside, clofarabine
  • 6-Amino-2-chloropurine-9-β-D-(2’-deoxy-2’-fluoro)arabinoriboside
  • Clofarabine USP/EP/BP
  • Antitumor drugs Clofarabine
  • ClofarabineQ: What is Clofarabine Q: What is the CAS Number of Clofarabine Q: What is the storage condition of Clofarabine Q: What are the applications of Clofarabine
  • 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
  • Clofarabine, 98%, a ribonucleotide reductase inhibitor
  • 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
  • Clolar
  • 200mg
  • 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
  • Clorabine
  • Clofarabine (100 mg)
  • Precision Clofarabine
  • 123318-82-1
  • 23318-82-1
  • C10H11ClFN5O3
  • Antineoplastic
  • Anti-cancer&immunity
  • Pharmaceutical intermediate
  • CLOLAR
  • Bases & Related Reagents
  • Nucleotides
  • Inhibitors
  • Intermediates & Fine Chemicals
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