5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidindion
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- CAS-Nr.
- 50-12-4
- Bezeichnung:
- 5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidindion
- Englisch Name:
- (S)-MEPHENYTOIN
- Synonyma:
- Epilan;Epiazin;Methoin;Metydan;Sacerno;Insulton;Fenantoin;Mesantoin;Mesontoin;NSC-34652
- CBNumber:
- CB0225135
- Summenformel:
- C12H14N2O2
- Molgewicht:
- 218.25
- MOL-Datei:
- 50-12-4.mol
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5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidindion Eigenschaften
- Schmelzpunkt:
- 135-138 °C
- Siedepunkt:
- 358.94°C (rough estimate)
- Dichte
- 1.154±0.06 g/cm3 (20 ºC 760 Torr)
- Brechungsindex
- 1.6660 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- Aggregatzustand
- solid
- pka
- pKa 8.1 (Uncertain)
- Farbe
- off-white
- CAS Datenbank
- 50-12-4(CAS DataBase Reference)
- EPA chemische Informationen
- Mephenytoin (50-12-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidindion Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5.
It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation
than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of
serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl-
5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside
but is still available outside the United States.
Verwenden
Anticonvulsant.
Biologische Aktivit?t
CYP2C19 substrate. Anticonvulsant.
Nebenwirkungen
Side effects, including rash, fever, and fatal blood dyscrasia, prevent the use as an anticonvulsant drug of first choice.
Sicherheitsprofil
Poison by ingestion and
intraperitoneal routes. Human systemic
effects by ingestion: somnolence,
hemorrhage, changes in teeth and
supporting structures. Human mutation data
reported. An experimental teratogen. An
FDA proprietary drug used as an
anticonvulsant. When heated to
decomposition it emits toxic fumes of NOx.
5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidindion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidindion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 106)Lieferanten
50-12-4(5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidindion)Verwandte Suche:
- (S)-(+)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE
- (S)-(+)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN
- (S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN
- (S)-(+)-MEPHENYTOIN
- (+/-)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE
- (+/-)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN
- (+/-)-MEPHENYTOIN
- MEPHENYTOIN
- Epiazin
- Epilan
- Fenantoin
- Gerot-epilan
- Hydantoin, 5-ethyl-3-methyl-5-phenyl-
- Insulton
- mephenetoinum
- Mephentoin
- Mesantoin
- Mesdontoin
- Mesontoin
- Methoin
- Methyl hydantoin
- Methylphenetoin
- Metydan
- NSC-34652
- Phenantoin
- Phenylethylmethylhydantoin
- Sacerno
- Sedantional
- Sedantoin
- Sedantoinal
- Triantoin
- 2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl-
- 3-Ethylnirvanol
- 3-Methyl-5,5-ethylphenylhydantoin
- 3-Methyl-5,5-phenylethylhydantoin
- 3-Methyl-5-ethyl-5-phenylhydantoin
- 5-Ethyl-3-methyl-5-phenyl-2,4(3H,5H)-imidazoledione
- 5-ethyl-3-methyl-5-phenyl-4-imidazolidinedione
- 5-ethyl-3-methyl-5-phenyl-hydantoi
- 5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dione
- 5-Ethyl-5-fenyl-3-methylhydantoin
- (±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione, (±)-5-Ethyl-3-methyl-5-phenylhydantoin
- DL-Mephenytoin
- (5R)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
- (5R)-5-Ethyl-3-methyl-5-phenylhydantoin
- (5R)-5α-Ethyl-3-methyl-5-phenylhydantoin
- 5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione
- 5-Ethyl-3-methyl-5-phenethylhydantoin
- 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
- Mephenytoin (250 mg)
- Mephenytoin-d3
- MEPHENYTOIN; METHOIN; MESANTOIN; PHENANTOIN; METHYLPHENETOIN; INSULTON.
- (S)-MEPHENYTOIN USP/EP/BP
- Mephenitoin
- rac-Mephenytoin/Mephenytoin
- Mephenytoin, 10 mM in DMSO
- (±)-Mephenytoin
- 50-12-4
