92-78-4
92-78-4 結(jié)構(gòu)式
基本信息
冰染偶合組分 10
色酚 AS-E
2-羥基-N-(4氯基苯基)-3-萘甲酰胺
納夫妥AS-E
萘酚AS-E
色酚AS-E
C.I.冰染偶合組分10
AZOIC COUPLING COMPONENT 10
c.i. azoic coupling component 10
N-(4-CHLOROPHENYL)-3-HYDROXY-2-NAPHTHAMIDE
NAPHTHOL AS-E
NAPTHOL AS-E
AcnaNaphtholPC
DaitoGrounderE
n-(4-chlorophenyl)-3-hydroxy-2-naphthalenecarboxamid
2-Hydroxy-3-Naphthoyl-p-Chloraniline
2-Naphthalenecarboxamide-N-(4-chlorophenyl)-3-hydroxy
4′-Chlor-3-hydroxy-2-naphthanilid
Naphthol AS-E (C.I. 37510)
4''-CHLORO-3-HYDROXY-2-NAPHTHANILIDE 97.0+%(T)
C.I. 37510
Amarthol AS-E
Kiwa Grounder E
Naftol AS-E
N-(4-Chlorophenyl)-3-hydroxynaphthalene-2-carboxamide
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-104068 | 色酚 AS-E Naphthol AS-E | 92-78-4 | 100mg | 600元 |
| 2024/08/19 | HY-104068 | 色酚 AS-E Naphthol AS-E | 92-78-4 | 10mM * 1mLin DMSO | 660元 |
| 2024/08/19 | C2103 | 4'-氯-3-羥基-2-萘苯胺 4'-Chloro-3-hydroxy-2-naphthanilide | 92-78-4 | 25G | 810元 |
常見問題列表
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KIX-KID 2.26 μM (IC 50 ) |
CREB (cyclic AMP-response element-binding protein) is a downstream transcription factor of a multitude of signaling pathways emanating from receptor tyrosine kinases or G-protein coupled receptors.CREB can not be activated until it is phosphorylated at Ser133 and its subsequent binding to CREB-binding protein (CBP) through the kinase-inducible domain (KID) in CREB and KID-interacting (KIX) domain in CBP.In a cell-based CREB Renilla luciferase reporter assay, Naphthol AS-E?inhibits CREB-mediated gene transcription with an IC 50 of 2.29 μM. In HEK293T-based complementation assay, Naphthol AS-E?dose-dependently inhibited Renilla luciferase activity with an IC 50 of 2.9 μM by directly binding to CBP's KIX domain (K d ~8.6 μM using a recombinant KIX).Naphthol AS-E?exhibits low μM activity in inhibiting the proliferation of all these cancer cells, which is consistent with its cellular CREB inhibition potency. The average GI 50 values for A549, MCF-7, MDA-MB-231 and MDA-MB-468 are approximately?2.9μM, 2.81μM, 2.35μM and 1.46μM, respectively.Naphthol AS-E (2.5 μM-10 μM; 48 hours) decreases the expression of anti-apoptotic protein Bcl-2. The expression of VEGF is also decreased.