7081-44-9
中文名稱
氯唑西林鈉
英文名稱
Sodium cloxacillin monohydrate
CAS
7081-44-9
分子式
C19H19ClN3NaO6S
MDL 編號
MFCD00150735
分子量
475.88
MOL 文件
7081-44-9.mol
更新日期
2025/01/09 10:25:45
7081-44-9 結構式
基本信息
中文別名
鄰氯苯甲異噁唑青霉素鈉鄰氯青霉素
鄰氯西林鈉
鄰氯苯唑西林鈉
氯唑西林鈉
鄰氯苯甲異惡唑青霉素鈉
鄰氯苯甲異唑青霉素鈉
3,3-二甲基-6-[5-甲基-3-(2-氯苯基)-4-異噁唑甲酰氨基]-7-氧代-4-硫雜-1-氮雜雙環(huán)[3.2.0]庚烷-2-甲酸鈉鹽
氯唑西林鈉
3,3-二甲基-6-[5-甲基-3-(2-氯苯基)-4-異唑甲酰氨基]-7-氧代-4-硫雜-1-氮雜雙環(huán)[3.2.0]庚烷-2-甲酸鈉鹽
英文別名
[5-METHYL-3-(O-CHLOROPHENYL)-4-ISOXAZOLYL]PENICILLIN SODIUM SALT MONOHYDRATECLOXACILLIN SODIUM SALT HYDRATE
CLOXACILLIN SODIUM SALT MONOHYDRATE
CLOXACILLIN SODIUM SALT N-HYDRATE
bactopen
brl-1621sodiumsaltmonohydrate
cloxacillinsodiummonohydrate
orbeninsodiumhydrate
prostaphlin-amonohydrate
sodiumcloxacillinmonohydrate
staphobristol-250
thyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-,sodiumsalt,monohydrate
CLOXACILLIN SODIUM SALT HYDRATE VETRANAL
CLOXACILLIN SODIUM EPC(CRM STANDARD)
CLOXACILLIN SODIUM USP(CRM STANDARD)
CLOXACILLIN SODIUM WHO(CRM STANDARD)
Cloxacillin sodium hydrate
4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chlorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-
3-(2-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin Sodium
Cloxacillin sodium
所屬類別
原料藥：青霉素類藥物理化學性質(zhì)
外觀性狀白色粉末或結晶性粉末。熔點170℃（分解）。易溶于水，溶于乙醇，微溶于氯仿，有引濕性，微臭，味苦。
熔點170℃
沸點689℃
閃點>110°(230°F)
儲存條件2-8°C
溶解度H2O中可溶50mg/mL
形態(tài)固體
顏色白色至橙色再至綠色
水溶解性溶于水
Merck13,2444
BRN5403885
CAS 數(shù)據(jù)庫7081-44-9(CAS DataBase Reference)
應用領域
用途一
該品為半合成抗菌素，與苯唑西林的作用特點和用途均極相似，對耐藥金葡菌該品有殺菌作用?？诜蚣∽⑽蛰^好，血濃度比苯唑西林高2倍，主要用于耐藥金葡菌所致感染，如敗血癥、骨髓炎、皮膚軟組織感染、心內(nèi)膜炎、泌尿系統(tǒng)感染及腦膜炎等療效較好。制備方法
方法一
鄰甲苯胺經(jīng)重氮化、置換、氯化、水解、肟化等操作。得到鄰氯苯甲肟氯，然后與乙酰乙酸乙酯環(huán)合、用五氯化磷氯化，得到3-鄰氯苯基-5-甲基-4異噁酰氯，最后與6-APA縮合得到鄰氯青霉素堿、加異辛酸鈉成鹽、即為鄰氯青霉素鈉。氯唑西林鈉一水合物價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/11 | XW708144901 | 鄰氯西林鈉一水合物 | 7081-44-9 | 1G | 250元 |
| 2024/11/08 | 45530 | 鄰氯西林鈉一水合物 Cloxacillin sodium salt monohydrate | 7081-44-9 | 1g | 876元 |
| 2024/11/08 | 45530 | 鄰氯西林鈉一水合物 Cloxacillin sodium salt monohydrate | 7081-44-9 | 5g | 2894元 |
常見問題列表
生物活性
Cloxacillin Sodium是Cloxacillin的鈉鹽形式，是一種耐青霉素酶，耐酸，半合成的青霉素。體外研究
Cloxacillin is an antibiotic useful for the study of a number of bacterial infections.
Cell Viability Assay
| Cell Line: | Strains M12 and M60. |
| Concentration: | 0.5 μg/mL. |
| Incubation Time: | 4-24 h. |
| Result: | Significantly reduced the bacterial numbers. |
體內(nèi)研究
Cloxacillin sodium (50 mg/kg, Subcutaneously) results a significant antibiotic efficacy against S. aureus .
| Animal Model: | Mice. |
| Dosage: | 10 mg/kg ( Pharmacological Analysis ). |
| Administration: | Given subcutaneously. |
| Result: | Reached a maximal concentration in plasma of 8.4 μg/mL at 10 min and had a half-life of approximately 15 min. |
| Animal Model: | Mice injected with approximately 2 × 10 6 CFU of bacteria in 0.1 mL saline were aseptically injected into the right thigh muscle. |
| Dosage: | 0–500 mg/kg. |
| Administration: | Subcutaneously in the nuchal region at 1 h after infection. |
| Result: | Resulted in a significant decrease in the number of viable S. aureus measured 18 h thereafter. |