339068-25-6
中文名稱
化合物 T11556
英文名稱
HET0016
CAS
339068-25-6
分子式
C12H18N2O
分子量
206.28
MOL 文件
339068-25-6.mol
更新日期
2023/03/20 15:41:27
339068-25-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11556N'-(4-丁基-2-甲基苯基)-N-羥基甲脒
N-羥基-N'-(4-正丁基-2-甲基苯基)甲IDINE
N-(4-丁基-2-甲基苯基)-N'-羥基甲基亞氨基酰胺
英文別名
HET0016N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine
N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE
N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide
N-(4-butyl-2-methylphenyl)-N'-hydroxyiminoformamide
N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE
Methanimidamide, N'-(4-butyl-2-methylphenyl)-N-hydroxy-
物理化學(xué)性質(zhì)
熔點(diǎn)138-140°C
儲(chǔ)存條件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度可溶于氯仿（少許）、乙醇（少許）
形態(tài)淡粉色固體。
顏色白色至淡黃色
CAS 數(shù)據(jù)庫(kù)339068-25-6
應(yīng)用領(lǐng)域
用途1
生物試劑用途2
HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other
CYP鈥檚: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models.
Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg).