1614-12-6
基本信息
1-氨基苯并三氮唑
1-苯并三唑胺
1-BENZOTRIAZOLAMINE
1H-1,2,3-BENZOTRIAZOL-1-YLAMINE
ABT
RARECHEM AQ NN 0550
TIMTEC-BB SBB004208
1-Benzotriazolylamine
1H-Benzotriazol-1-amine
1H-Benzotriazole,1-amino-
Benzotriazol-1-ylamine
1-Aminobenzotriazole 97%
ABT, 1-Benzotriazoleamine
1-Benzotriazolamine, ABT
1-(Thiophen-2-yl)-4-[(2-aminoethyl)amino]-1-butanone
4-[(2-Aminoethyl)amino]-1-(2-thienyl)butan-1-one
1-Amino-1H-benzotriazole
物理化學性質
安全數(shù)據(jù)
知名試劑公司產(chǎn)品信息
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/11 | XW161412602 | 1-氨基苯并三唑 | 1614-12-6 | 1G | 282元 |
2024/11/08 | 34864 | 1-氨基苯并三唑 1-Aminobenzotriazole, 98%, Thermo Scientific Chemicals | 1614-12-6 | 100mg | 1512元 |
2024/11/08 | 34864 | 1-氨基苯并三唑 1-Aminobenzotriazole, 98%, Thermo Scientific Chemicals | 1614-12-6 | 250mg | 2823元 |
常見問題列表
Target | Value |
P450
() | |
NAT
() |
1-Aminobenzotriazole (ABT) alone significantly increases the expression levels of CYP2B6 in two different hepatocytes (7.3- and 10.8-fold, respectively). Upon co-treatment with 1-Aminobenzotriazole, the induction of CYP2B6 expression by CITCO or rifampin is potentiated: 12.6- and 4.0-fold for CITCO as well as 3.9- and 2.5-fold for rifampin. 1-Aminobenzotriazole has a greater potentiation effect on CITCO than on rifampin. 1-Aminobenzotriazole alone increases the expression levels of CYP3A4 in tow different hepatocytes (by 2.0- and 3.8-fold). Upon co-treatment with 1-Aminobenzotriazole, the effects of CITCO on CYP3A4 expression levels are potentiated by 3.8- and 6.0- fold as compare to cells treated with CITCO alone. 1-Aminobenzotriazole (ABT) (1 mM) shows pronounced (~95%) inhibition of the formation of N-acetylprocainamide compare with the control without 1-Aminobenzotriazole.
Oral 1-Aminobenzotriazole (ABT) (100 mg/kg, 2 h predose) decreases the clearance of intravenous procainamide (45%) in rats, accompanied by a decreased N-acetylprocainamide-to-procainamide ratio in urine (0.74 versus 0.21) and plasma (area under the curve ratio 0.59 versus 0.11). The urinary recovery of procainamide increases from 18 to 30%, whereas the recovery of N-acetylprocainamide in urine decreases from 13.3 to 6.5% with 1-Aminobenzotriazole. Pretreatment of rats with 100 mg/kg oral 1-Aminobenzotriazole (ABT) administered 2 hours before a semisolid caloric test meal markedly delays gastric emptying. 1-Aminobenzotriazole also increases stomach weights by 2-fold.