144689-24-7
144689-24-7 結(jié)構(gòu)式
基本信息
奧美沙坦
4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Olmesartan
4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2’-(1H-tetazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid
CS 088
Olmesartan Acid
RNH 6270
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
Olmesartan (0.7-5 mM; 24, 48 and 72?h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode.
Cell Viability Assay
| Cell Line: | Human cervical cancer cell line (HeLa) |
| Concentration: | 0.7- 5 mM |
| Incubation Time: | 24, 48 and 72?h |
| Result: | IC 50 s against HeLa cell line are 4.685 and 1.651 mM for 48 and 72 h, respectively. |
Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.